Wo to them that are mighty to drink wine! Isaiah now censures another vice, namely, drunkenness and excess in eating, of which he had spoken before; so that probably this chapter is collected from various sermons, and the leading topics only are briefly touched; for when the Prophet saw no repentance, he was forced to repeat and frequently inculcate the same instructions. He therefore returns to the same reproofs which he had previously noticed; for he again discourses about drunkenness, luxury, covetousness, and other corruptions. Hence we ought to conclude, that when warnings produce no good effect, we ought to employ greater earnestness in addressing the obstinate and disobedient, and that we must not be afraid of giving offense by our eagerness, but must frequently repeat the reproofs, until they either yield or manifest incurable malice. By calling them strong or powerful to drink, he wittily accuses them of wasting their strength in bacchanalian warfare. It is disgraceful and beastly ambition, when a man of vigorous health makes a display of his strength by drinking largely. Employing a figure of speech (synecdoche) which is frequent in the Prophets, and indeed in the whole of Scripture, he takes a part for the whole; as if he had said, "Wo to gluttony; Wo to intemperance." But he purposely mentioned that which was disgraceful in the highest degree, in order to render that vice generally hated and abhorred; for, as we have said, nothing is more base or disgraceful than for a man to make trial of his strength in swallowing food or in guzzling wine, and thus struggling with himself so as to cram down as much as his belly can hold. Such men keep by no rule of life, and do not know why God gives them nourishment; for we eat and drink to support the body, and not to destroy it. We live that we may yield worship and obedience to God, and that we may render assistance to our neighbors. When men act so as not to maintain their strength, but to destroy it by trying how much food and wine they can bear, most certainly they are worse than beasts.

Wo unto them that are mighty - This is the sixth specification of crime. He had already denounced the intemperate in Isaiah 5:11. But probably this was a prevailing sin. Perhaps there was no evidence of reform; and it was needful to "repeat" the admonition, in order that people might be brought to regard it. The prophet repeats a similar denunciation in Isaiah 56:12.
Mighty - Perhaps those who prided themselves on their ability to drink "much" without becoming intoxicated; who had been so accustomed to it, that they defied its effects, and boasted of their power to resist its usual influence. A similar idea is expressed in Isaiah 56:12.
Men of strength - The Chaldee understands this of "rich" men; but, probably, the reference is to those who boasted that they were able to bear "much" strong drink.
To mingle - To mix wine with spices, dates, drugs, etc., to make it more intoxicating; Proverbs 9:2, Proverbs 9:5. They boasted that they were able to drink, without injury, liquor of extraordinary intoxicating qualities.
Strong drink - Note, Isaiah 5:11. On the subject of the strong drink used in the East, "see Harmer's Observations," vol. ii. pp. 140-148. Ed. Lond. 1808.

Mighty to drink wine - "They show not," says Kimchi, "their strength in combating their enemies, but in drunkenness and debauchery."

Woe to [them that are] (c) mighty to drink wine, and men of strength to mix strong drink:
(c) Who are never weary, but show their strength, and brag in gluttony and drunkenness.

Woe unto them that are mighty to drink wine,.... That can bear a great deal, and not be overcome and intoxicated with it; that try their strength this way with others, and get the mastery and glory in it: not mighty to fight their enemies, as Kimchi observes, and defend their country, but to drink wine; by which their strength was weakened: wherefore some think soldiers are particularly designed, given to drinking, who are derided and mocked, as being valiant in the warfare of Bacchus, and not of Mars:
and men of strength, to mingle strong drink; in the cup, and then drink it: or "men of war"; the same with "mighty" before. The Targum interprets it, "men of riches": who can afford to drink wine and strong drink; which carries the sense not to the strength of their bodies, but of their purses: the former sense seems best. The Scribes and Pharisees loved the cup and the platter, and to be at feasts, and to have the uppermost seats there, Matthew 23:6 and that those that sat in Moses's chair are intended appears from the following words.

Sixth Woe--against corrupt judges, who, "mighty" in drinking "wine" (a boast still not uncommon), if not in defending their country, obtain the means of self-indulgence by taking bribes ("reward"). The two verses are closely joined [MAURER].
mingle strong drink--not with water, but spices to make it intoxicating (Proverbs 9:2, Proverbs 9:5; Song 8:2).
take away the righteousness--set aside the just claims of those having a righteous cause.

The sixth woe: "Woe to those who are heroes to drink wine, and brave men to mix strong drink; who acquit criminals for a bribe, and take away from every one the righteousness of the righteous." We see from Isaiah 5:23 that the drinkers in Isaiah 5:22 are unjust judges. The threat denounced against these is Isaiah's universal ceterum censeo; and accordingly it forms, in this instance also, the substance of his sixth and last woe. They are heroes; not, however, in avenging wrong, but in drinking wine; they are men of renown, though not for deciding between guilt and innocence, but for mixing up the ingredients of strong artistic wines. For the terms applied to such mixed wines, see Psalm 75:9; Proverbs 23:30, Song 7:3. It must be borne in mind, however, that what is here called shecâr was not, properly speaking, wine, but an artificial mixture, like date wine and cider. For such things as these they were noteworthy and strong; whereas they judged unjustly, and took bribes that they might consume the reward of their injustice in drink and debauchery (Isaiah 28:7-8; Proverbs 31:5). "For reward:" ēkeb (Arab. ‛ukb; different from âkēb, a heel, = ‛akib) is an adverbial accusative, "in recompense," or "for pay." "From him" (mimmennu) is distributive, and refers back to tsaddikim (the righteous); as, for example, in Hosea 4:8.

To mingle - To drink: the antecedent being put for the consequent: for they mingled it in order to drinking.