Wo to them that are wise in their own eyes! Here he proceeds to rebuke those on whom no instruction can produce a good effect, and who do not allow any wise counsels or godly warnings to gain admission. In short, he pronounces a curse on obstinate scorners, who set up either the lusts of the flesh or a preposterous confidence in their wisdom, in opposition to God's instruction and warnings. And not only does he rebuke those who are puffed up with a false conviction of their wisdom, and are ashamed to learn from others, but he likewise pronounces a general condemnation on all who, through prejudices in their own favor, refuse to hear God speaking, and to listen to his holy warnings. This fault has been too common in all ages, and we see it in very many persons at the present day, who, though they would shrink from openly rejecting the doctrine of godliness, are yet so far from being truly obedient and teachable, that they haughtily reject everything that does not please them. They acknowledge that they need some bridle, but, on the other hand, are so much blinded by their presumption, that, when God points out the way, they immediately rebel; and not only so, but break out into violent indignation at the censure passed on their proceedings. Nay, where is the man who renounces his own judgment, and is ready to learn only from the mouth of God? But nothing is more destructive than this deceitful show of wisdom; for the beginning of piety is willingness to be taught, when we have renounced our own judgment and follow wherever God calls. Nor is this false belief condemned solely on the ground of its rendering men disobedient to God, and thus being the cause of their ruin, but also on the ground of being in itself what God cannot endure. We must become fools if we desire to be God's disciples. But it is also certain that mad rebellion reigns wherever there is not found that modesty and humility which leads a man willingly to yield subjection, In their own eyes means what we say in French, a leur semblant, that is, in their own conceit

Wo unto them that are wise - This is the fifth crime specified. It refers to those who are inflated with a false opinion of their own knowledge, and who are, therefore, self-confident and vain. This is expressly forbidden; Proverbs 3:7 : 'Be not wise in thine own eyes;' compare Proverbs 26:12.
In their own eyes - In their own opinion, or estimation.
And prudent - Knowing; self-conceited. This was, doubtless, one characteristic of the times of Isaiah. It is known to have been strikingly the characteristic of the Jews - particularly the Pharisees - in the time of our Saviour. The evil of this was,
(1) That it evinced and fostered "pride."
(2) That it rendered them unwilling to be instructed, and especially by the prophets.
As they supposed that they were already wise enough, they refused to listen to others. This is always the effect of such self-confidence: and hence, the Saviour required his disciples to be meek, and humble, and teachable as children.

Woe to [them that are] (b) wise in their own eyes, and prudent in their own sight!
(b) Who contemn all doctrine and admonition.

Woe unto therm that are wise in their own eyes,.... And yet betray such stupidity and sottishness, as to call things by their wrong names; and make such a perverse judgment of them, as before described. This is a true description of the Scribes and Pharisees in Christ's time; who said, "dost thou teach us? are we blind also?" John 9:34.
and prudent in their own sight; being wise above what was written; leaving the word of God, and following the traditions of the elders.

Fifth Woe--against those who were so "wise in their own eyes" as to think they knew better than the prophet, and therefore rejected his warnings (Isaiah 29:14-15).

The fifth woe: "Woe unto them that are wise in their own eyes, and prudent in their own sight." The third woe had reference to the unbelieving naturalists, the opponents of prophecy (nebuâh); the fourth to the moralists, who threw all into confusion; and to this there is appended, by a very natural association of ideas, the woe denounced upon those whom want of humility rendered inaccessible to that wisdom which went hand in hand with prophecy, and the true foundation of which was the fear of Jehovah (Proverbs 1:7; Job 28:28; Ecclesiastes 12:13). "Be not wise in thine own eyes," is a fundamental rule of this wisdom (Proverbs 3:7). It was upon this wisdom that that prophetic policy rested, whose warnings, as we read in Isaiah 28:9-10, they so scornfully rejected. The next woe, which has reference to the administration of justice in the state, shows very clearly that in this woe the prophet had more especially the want of theocratic wisdom in relation to the affairs of state in his mind.