Be not thou, then, far from me, O Jehovah! We must keep in mind all that David has hitherto related concerning himself. As his miseries had reached the utmost height, and as he saw not even a single ray of hope to encourage him to expect deliverance, it is a wonderful instance of the power of faith, that he not only endured his afflictions patiently, but that from the abyss of despair he arose to call upon God. Let us, therefore, particularly mark, that David did not pour out his lamentations thinking them to be in vain, and of no effect, as persons who are in perplexity often pour forth their groanings at random. The prayers which he adds sufficiently show that he hoped for such an issue as he desired. When he calls God his strength, by this epithet he gives a more evident proof of his faith. He does not pray in a doubting manner; but he promises himself the assistance which the eye of sense did not as yet perceive. By the sword, by the hand of the dog, by the mouth of the lion, and by the horns of the unicorns, he intimates that he was presently exposed to the danger of death, and that in many ways. Whence we gather, that although he utterly fainted in himself when thus surrounded by death, he yet continued strong in the Lord, and that the spirit of life had always been vigorous in his heart. Some take the words only soul, or only life, for dear and precious; [1] but this view does not appear to me to be appropriate. He rather means, that, amidst so many deaths he found no help or succor in the whole world; as in Psalm 35:17 the words, only soul, are used in the same sense for a person who is alone and destitute of all aid and succor. This will appear more clearly from Psalm 25:16, where David, by calling himself poor and alone, doubtless complains that he was completely deprived of friends, and forsaken of the whole world. When it is said in the end of the 21st verse, Answer me, or, Hear me from the horns of the unicorns, this Hebrew manner of speaking may seem strange and obscure to our ears, but the sense is not at all ambiguous. The cause is only put instead of the effect; for our deliverance is the consequence or effect of God's hearing us. If it is asked how this can be applied to Christ, whom the Father did not deliver from death? I answer, in one word, that he was more mightily delivered than if God had prevented him from falling a victim to death, even as it is a much greater deliverance to rise again from the dead than to be healed of a grievous malady. Death, therefore, did not prevent Christ's resurrection from at length bearing witness that he had been heard.

Footnotes

1 - That is, my life, which is dear and precious to me.

But be not thou far from me, O Lord - "O Yahweh." Others - all others - have forsaken me, and left me to perish. Now, in the day of my desertion and my peril, be thou near to me. See Psalm 22:11. This is the burden of the prayer in the whole psalm, that God would not leave him, but sustain and deliver him. Compare Psalm 22:1.
O my strength - Source of my strength; thou on whom I rely for support and deliverance.
Haste thee to help me - Help me speedily. Come to support me; come to deliver me from these dreadful sorrows. This is not necessarily a prayer to be rescued from death, but it would be applicable to deliverance from those deep mental sorrows that had come upon him - from this abandonment to unutterable woes.

Be not thou far from me - In the first verse he asks, Why hast thou forsaken me? Or, as if astonished at their wickedness, Into what hands hast thou permitted me to fall? Now he prays, Be not far from me. St. Jerome observes here, that it is the humanity of our blessed Lord which speaks to his divinity. Jesus was perfect man; and as man he suffered and died. But this perfect and sinless man could not have sustained those sufferings so as to make them expiatory had he not been supported by the Divine nature. All the expressions in this Psalm that indicate any weakness as far as it relates to Christ, (and indeed it relates principally to him), are to be understood of the human nature; for, that in him God and man were united, but not confounded, the whole New Testament to me bears evidence, the manhood being a perfect man, the Godhead dwelling bodily in that manhood. Jesus, as Mans, was conceived, born, grew up, increased in wisdom, stature, and favor with God and man; hungered, thirsted, suffered, and died. Jesus, as God, knew all things, was from the beginning with God, healed the diseased, cleansed the lepers, and raised the dead; calmed the raging of the sea, and laid the tempest by a word; quickened the human nature, raised it from the dead, took it up into heaven, where as the Lamb newly slain, it ever appears in the presence of God for us. These are all Scripture facts. The man Christ Jesus could not work those miracles; the God in that man could not have suffered those sufferings. Yet one person appears to do and suffer all; here then is God manifested in the Flesh.
O my strength - The divinity being the poxver by which the humanity was sustained in this dreadful conflict.

But be not thou far from me, O Lord,.... See Gill on Psalm 22:11;
O my strength; Christ as God is the mighty God, the Almighty; as Mediator, he is the strength of his people; but, as man, God is his strength; he is the man of his right hand, whom he has made strong for himself, and whom he has promised his arm shall strengthen, Psalm 80:17; and therefore he addresses him in this manner here, saying,
haste thee to help me; his help was alone in God his strength; there were none that could help him but he, and he seemed to stand afar off from helping him, Psalm 22:1; and his case being so distressed, as is represented in the preceding verses, it required haste.

He now turns with unabated desire and trust to God, who, in His strength and faithfulness, is contrasted with the urgent dangers described.

(Hebrews.: 22:20-22)In Psalm 22:19 the description of affliction has reached its climax, for the parting of, and casting lots for, the garments assumes the certain death of the sufferer in the mind of the enemies. In Psalm 22:20, with ואתּה the looks of the sufferer, in the face of his manifold torments, concentrate themselves all at once upon Jahve. He calls Him אילוּתי nom. abstr. from איל, Psalm 88:5 : the very essence of strength, as it were the idea, or the ideal of strength; lė‛ezrāthi has the accent on the penult., as in Psalm 71:12 (cf. on the other hand Ps 38:23), in order that two tone syllables may not come together. In Psalm 22:21, חרב means the deadly weapon of the enemy and is used exemplificatively. In the expression מיּד כּלב, מיּד is not merely equivalent to מן, but יד is, according to the sense, equivalent to "paw" (cf. כּף, Leviticus 11:27), as פּי is equivalent to jaws; although elsewhere not only the expression "hand of the lion and of the bear," 1-Samuel 17:37, but also "hands of the sword," Psalm 63:11, and even "hand of the flame," Isaiah 47:14 are used, inasmuch as יד is the general designation of that which acts, seizes, and subjugates, as the instrument of the act. Just as in connection with the dog יד, and in connection with the lion פי (cf. however, Daniel 6:28) is mentioned as its weapon of attack, the horns, not the horn (also not in Deuteronomy 33:17), are mentioned in connection with antilopes, רמים (a shorter form, occurring only in this passage, for ראמים, Psalm 29:6; Psalm 34:7). Nevertheless, Luther following the lxx and Vulgate, renders it "rescue me from the unicorns" (vid., thereon on Psalm 29:6). יהידה, as the parallel member here and in Psalm 35:17 shows, is an epithet of נפשׁ. The lxx in both instances renders it correctly τὴν μονογενῆ μου, Vulg. unicam meam, according to Genesis 22:2; Judges 11:34, the one soul besides which man has no second, the one life besides which man has no second to lose, applied subjectively, that is, soul or life as the dearest and most precious thing, cf. Homer's fi'lon kee'r. It is also interpreted according to Psalm 25:16; Psalm 68:7 : my solitary one, solitarium, the soul as forsaken by God and man, or at least by man, and abandoned to its own self (Hupfeld, Kamphausen, and others). But the parallel נפשׁי, and the analogy of כּבודי (= נפשׁי), stamp it as an universal name for the soul: the single one, i.e., that which does not exist in duplicate, and consequently that which cannot be replaced, when lost. The praet. עניתני might be equivalent to ענני, provided it is a perf. consec. deprived of its Waw convers. in favour of the placing of מקּרני רמים first for the sake of emphasis; but considering the turn which the Psalm takes in Psalm 22:23, it must be regarded as perf. confidentiae, inasmuch as in the very midst of his supplication there springs up in the mind of the suppliant the assurance of being heard and answered. To answer from the horns of the antilope is equivalent to hearing and rescuing from them; cf. the equally pregnant expression ענה בּ Psalm 118:5, perhaps also Hebrews 5:7.
(Note: Thrupp in his Emendations on the Psalm (Journal of Classic and Sacred Philology, 1860) suggests עניּתי, my poverty (my poor soul), instead of עניתני.)