Depart not far from me. Here he employs another argument to induce God to show him mercy, alleging that he is sorely pressed and hemmed in by the greatest distress. He doubtless set before his eyes the office which the Scriptures every where attribute to God of succouring the miserable, and of being the more ready to help us the more we are afflicted. Even despair itself, therefore, served as a ladder to elevate his mind to the exercise of devout and fervent prayer. In like manner, the feeling we have of our afflictions should excite us to take shelter under the wings of God, that by granting us his aid, he may show that he takes a deep interest in our welfare.

Be not far from me - Do not withdraw from me; do not leave or forsake me.
For trouble is near - Near, in the sense that deep sorrow has come upon me; near, in the sense that I am approaching a dreadful death.
For there is none to help - Margin, as in Hebrew, "not a helper." There were those who would have helped, but they could not; there were those who could have helped, but they would not. His friends that stood around the cross were unable to aid him; his foes were unwilling to do it; and he was left to suffer unhelped.

Be not far from me; for trouble is near - A present God is a present blessing. We always need the Divine help; but more especially when troubles and trials are at hand.

Be not far from me,.... Who had been so near unto him, as to take him out of the womb, and to take the care of him ever since; this is to be understood not with respect to the omnipresence of God, who is everywhere, and is not far from any of us; but of his presence, which was now withdrawn from Christ, and he was filled with a sense of divine wrath, and with sorrow and distress; and also of his powerful and assisting presence which he had promised, and Christ expected, and believed he should have, as he had: the reasons for it follow:
for trouble is near; Satan was marching towards him with his principalities and powers, to attack him in the garden and on the cross; Judas, one of his own disciples, was at hand to betray him; a multitude with swords and staves were about to seize him; the sins and chastisement of his people were just going to be laid upon him; the sword of justice was awaked against him, ready to give the blow; the hour of death was near, he was brought to the dust of it, as in Psalm 22:15. A second reason is given,
for there is none to help; none among his disciples: one of them was to betray him, another to deny him, and all to forsake him and flee from him, as they did; nor any among the angels in heaven; for though they ministered to him in the wilderness, and strengthened him in the garden, there were none near him on the cross, that it might be manifest that salvation was wrought out alone by him, Isaiah 63:5; and, indeed, if any of these had been willing to have helped him, it was not in their power to do it, none but God could; and therefore he applies to him, who had promised and was as good as his word, Isaiah 49:8.

In these verses we have Christ suffering, and Christ praying; by which we are directed to look for crosses, and to look up to God under them. The very manner of Christ's death is described, though not in use among the Jews. They pierced his hands and his feet, which were nailed to the accursed tree, and his whole body was left so to hang as to suffer the most severe pain and torture. His natural force failed, being wasted by the fire of Divine wrath preying upon his spirits. Who then can stand before God's anger? or who knows the power of it? The life of the sinner was forfeited, and the life of the Sacrifice must be the ransom for it. Our Lord Jesus was stripped, when he was crucified, that he might clothe us with the robe of his righteousness. Thus it was written, therefore thus it behoved Christ to suffer. Let all this confirm our faith in him as the true Messiah, and excite our love to him as the best of friends, who loved us, and suffered all this for us. Christ in his agony prayed, prayed earnestly, prayed that the cup might pass from him. When we cannot rejoice in God as our song, yet let us stay ourselves upon him as our strength; and take the comfort of spiritual supports, when we cannot have spiritual delights. He prays to be delivered from the Divine wrath. He that has delivered, doth deliver, and will do so. We should think upon the sufferings and resurrection of Christ, till we feel in our souls the power of his resurrection, and the fellowship of his sufferings.

From this statement of reasons for the appeal, he renews it, pleading his double extremity, the nearness of trouble, and the absence of a helper.