My persecutors and oppressors are many. The Psalmist here as in other places testifies, that although he had been provoked by many injuries, yet he had not departed from the right way; which, as I have elsewhere observed, was an evidence of great and singular constancy. It is an easy matter to act well when we are among the good; but if wicked men afflict us, if one man openly assault us by force, if another rob us of our property, if a third circumvent us by wiles, and a fourth attack us by calumnies, it is difficult for us to persevere in our integrity, and we rather begin to howl among the wolves. Besides, the license which is allowed them of doing what they please without the fear of being punished, is a powerful engine for shaking our faith, because, when God thus winks at the wicked, he seems to abandon us for a prey. The Prophet therefore, by God's testimonies, means not only the rule of holy and righteous living, but also the promises. Lord, as if he had said, I have not turned away from the path of integrity, although the conduct of the wicked has presented me with a temptation to do so; nor have I shaken off nay confidence in thy grace, but have waited patiently for thy succor. Both these are necessary. For although he who has suffered wrongs may contend against the malice of his enemies by his well -- doing, and may refrain from every act of retaliation, yet, provided he does not depend wholly upon God, this uprightness will not be sufficient to save him. Not that any man behaves himself in a manner so moderate, except he who leans upon God and waits upon him as his deliverer; but granting that such could be the ease, there would not be sufficient power in this half virtue to save him. The salvation of God is reserved for the faithful who ask it in the exercise of lively faith. And whoever, persuaded that God will be his deliverer, pillars and supports his mind on the divine promises, will endeavor also to overcome evil with good.

Many are my persecutors and mine enemies - The thought here turns on the number of his enemies, and on the effect which numbers might have in turning one from the way of truth. We might meet one such enemy, and overcome him; we might resist the influence of one in endeavoring to turn us away from the truth, but the danger of falling is much increased when numbers are combined in persecuting us, or in seeking to turn us away from our religion - when it becomes unpopular to be a professed friend of God.
Yet do I not decline from thy testimonies - I still adhere to thee; I still maintain my integrity, notwithstanding all this. See the notes at Psalm 119:51.

Many are my persecutors and mine enemies,.... Because they were his enemies, therefore they were his persecutors; and they became enemies to him, or hated him, because of his religion, and on that account persecuted him: and this has always been the lot and case of God's people in all ages; and whose persecutors are many, even the whole world, as well as fierce and furious;
yet do I not decline from thy testimonies; from reading and hearing the word of God; and from embracing and professing the doctrines contained in it; and from the worship of God according to it, for which he was hated and persecuted: yet none of these things moved him from them, which showed that his heart was principled with the grace of God; for otherwise, when persecution arises because of the word, carnal professors are offended, and apostatize from it; see Matthew 13:22.

(Compare Psalm 119:86-87, Psalm 119:95).