As the cloud is consumed and vanisheth away - This image is taken from the light and fleecy clouds, which become smaller and smaller until they wholly vanish. For an illustration of a similar phrase, see the notes at Isaiah 44:22.
To the grave - - שׁאול she'ôl. Septuagint, εἰς ᾅδην eis hadēn, to Hades. The word may mean grave, or the place of departed spirits; see Isaiah 5:14, note; Isaiah 14:9, note; compare the notes at Job 10:21-22. Either signification will apply here.
Shall come up no more - Shall no more live on the earth. It would be pressing this too far to adduce it as proving that Job did not believe in the doctrine of the resurrection. The connection here requires us to understand him as meaning only that he would not appear again on the earth.

As the cloud is consumed - As the cloud is dissipated, so is the breath of those that go down to the grave. As that cloud shall never return, so shall it be with the dead; they return no more to sojourn with the living. See on the following verses.

(e) [As] the cloud is consumed and vanisheth away: so he that goeth down to the grave shall (f) come up no [more].
(e) If you behold me in your anger I will not be able to stand in your presence.
(f) Shall no more enjoy this mortal life.

As the cloud is consumed and vanisheth away,.... Which being dispersed by the wind, or broke up by the sun, is never seen, or returns more; for though the wise man speaks of clouds returning after the rain, this is not to be understood of the same clouds, but of succeeding ones, Ecclesiastes 12:2; so pardon of sin is expressed by the same metaphor, to show that sin thereby is no more, no more to be seen or remembered, Isaiah 43:25; the Targum renders it "as smoke", by which the shortness and consumption of men's days are expressed, Psalm 102:3; but by the simile of a cloud here is not so much designed the sudden disappearance of life as the irrevocableness of it when gone, as the reddition or application following shows:
so he that goeth down to the grave shall come up no more; the grave is the house or long home that all must go to, it being the appointment of God that all should die, or be in the state of the dead; which is meant by the grave, since all are not interred in the earth; and this, as here, is frequently expressed, as if it was man's act being hither brought; and when it designs an interment in the earth, it is with great propriety called a going down; and however that be, yet the state of the dead is a state of humiliation, a coming down from all the grandeur, honour, and glory of the present state, which are all laid in the dust; and when this is man's case, he comes up no more from it, that is, of himself, by his own power; none but Christ, who is God over all, ever did this; or none naturally, or by the laws of nature, for noticing short of almighty power can effect this; it must be done in an extraordinary way, and is no less than a miraculous operation; nor will this be done until the general resurrection of the just and unjust, when all that are in their graves shall come forth, the one to the resurrection of life, and the other to the resurrection of damnation; excepting in some few instances, as the Shunammite's son, 2-Kings 4:32; the man that touched the bones of the prophet Elisha, 2-Kings 13:21; the daughter of Jairus, Mark 5:41; the widow of Nain's son, Luke 7:14; Lazarus, John 11:43; and those that rose at our Lord's resurrection, Matthew 27:53; this is further explained in Job 7:10.

(2-Samuel 12:23).
the grave--the Sheol, or place of departed spirits, not disproving Job's belief in the resurrection. It merely means, "He shall come up no more" in the present order of things.

No more - Never until the general resurrection. When we see a cloud which looked great, as if it would eclipse the sun, of a sudden dispersed and disappearing, say, Just such a thing is the life of man, a vapour that appears for a while and then vanisheth away.