Men shall clap their hands at him - That is, they shall combine to drive him out of the world, and rejoice when he is gone. The same sentiment was also expressed by Bildad, Job 18:18 :
"He shall be driven fromm light into darkness,
And chased out of the world."
There can be no doubt, I think, that Job alludes to that sentiment, and that his object in quoting it is to show its incorrectness. He does not indeed go into a formal reply to it in the following chapters, but he seems to consider that he had already replied to it by the statements which he had made, and which showed the incorrectness of the views which his friends had taken. He had demonstrated in the previous chapters that their main position was incorrect, and he asks (in Job 27:12 of this chapter), how it was possible that they could hold such sentiments as these, in the midst of all the facts which surrounded them? The whole current of events was against their opinion, and in the close of this chapter he enumerates the sentiments which they had advanced, which he regarded as so strange, and which he felt that he had now shown to be erroneous. In deed, they seem to have regarded themselves as confuted, for they were silent. Job had attacked and overthrown their main position, that people were treated according to their character in this life, and that consequently extraordinary sufferings were proof of extraordinary guilt, and, that being overthrown, they had nothing more to say. Having silenced them, and shown the error of the opinions which he has here enumerated, be proceeds in the following chapters to state his own views on important topics connected with the providence of God, mainly designed to show that we are not to expect fully to comprehend the reason of his dispensations.

Men shall clap their hands at him - These two verses refer to the storm, which is to sweep away the ungodly; therefore the word God, in Job 27:22, and men in this verse, should be omitted.
Job 27:22 : "For it shall fall upon him, and not spare: flying from its power he shall continue to fly.
Job 27:23. It shall clap its hands against him, and hiss, וישרק veyishrok, shriek, him out of his place."
Here the storm is personified and the wicked actor is hissed and driven by it from off the stage. It seems it was an ancient method to clap the hands against and hiss a man from any public office, who had acted improperly in it. The populace, in European countries, express their disapprobation of public characters who have not pleased them in the same manner to the present day, by hisses, groans, and the like.

Men shall clap their hands at him,.... In a way of joy and triumph, scorn and derision, see Lamentations 2:15; either at the time of his death, being glad they are rid of him, Psalm 52:5; or rather hereafter, to all eternity, while the wrath and vengeance of God is pouring on him; and this will be done by all righteous men evermore; not pleasing themselves with the shocking scene, nor indulging any evil passion in them, from which they will be entirely free; but rejoicing in the glory of divine justice, which will be displayed in the everlasting destruction of wicked men, see Revelation 18:20; and this need not be restrained to good men only, but ascribed to angels also; for it may be rendered impersonally, "hands shall be clapped at him"; or joy be expressed on this occasion by all in heaven, angels and saints, who will all approve and applaud the divine procedure against wicked men as right and just; yea, this may express the glorying of divine justice, and its triumph in the condemnation and destruction of sinners;
and shall hiss him out of his place; from the bar and tribunal of God, where he stood and was condemned; and, as he goes to everlasting punishment, expressing abhorrence and detestation of him and his crimes, and as pleased with the righteous judgment of God upon him. Now this is the wicked man's portion, and the heritage he shall have of God at and after death, though he has been in flourishing circumstances in life; all which Job observes, to show that he was no friend nor favourer of wicked men, nor thought well of them and their ways, though he observed the prosperity they are attended with in their present state; and as for himself, he was not, and would not, be such a wicked man, and an hypocrite, on any account whatever, since he was sure he must then be miserable hereafter, to all intents and purposes.

clap . . . hands--for joy at his downfall (Lamentations 2:15; Nahum 3:19).
hiss--deride (Jeremiah 25:9). Job alludes to Bildad's words (Job 18:18).
In the twenty-seventh chapter Job had tacitly admitted that the statement of the friends was often true, that God vindicated His justice by punishing the wicked here; but still the affliction of the godly remained unexplained. Man has, by skill, brought the precious metals from their concealment. But the Divine Wisdom, which governs human affairs, he cannot similarly discover (Job 28:12, &c.). However, the image from the same metals (Job 23:10) implies Job has made some way towards solving the riddle of his life; namely, that affliction is to him as the refining fire is to gold.

Clap - In token of their joy at the removal of such a publick pest, by way of astonishment: and in contempt and scorn, all which this gesture signifies in scripture use. His - In token of detestation and derision.