For God shall cast upon him - That is, God shall bring calamities upon him, or cast his thunderbolts upon him, and shall not pity him.
He would fain flee - He would gladly escape from the wrath of God, but he is unable to do it.

God shall cast upon him - Or, rather, the storm mentioned above shall incessantly pelt him, and give him no respite; nor can he by any means escape from its fury.

For God shall cast upon him, and not spare,.... Cast his sins upon him, which will lie as an intolerable weight upon his conscience; and his wrath upon him, which being poured out like fire, he will not be able to bear it; and deserved punishment on him, which, like a talent of lead, will bear him down to the lowest hell; and this will be done without showing any mercy at all; for, though the wicked have much of sparing mercy in this world, they have none in the next; there is sparing mercy now, but none in hell; God, that spared not the angels that sinned, nor the old world, nor Sodom and Gomorrah, will not spare them, 2-Peter 2:4; he that made them will have no mercy on them; and he that formed them will show them no favour:
he would fain flee out of his hands; in whose hands he is, not as all men are, being the works of his hands, and supported by him; much less as his people are, secure there; but in his hands as an awful and terrible Judge, condemning him for his sins, and sentencing him to everlasting punishment; and a fearful thing it is to fall into the hands of the living and almighty God: there is no getting out of them, though "fleeing, he flees", as the phrase is, with all his might and main, with all the swiftness he can; it is all to no purpose; he is where he was, and must continue in the torment and misery he is in to all eternity; his worm of conscience will never die, nor the fire of divine wrath be ever quenched; though he will desire death ten thousand times over, he shall not find it, it shall flee from him, Revelation 9:6.

cast--namely, thunderbolts (Job 6:4; Job 7:20; Job 16:13; Psalm 7:12-13).

Cast - His darts or plagues one after another. Would flee - He earnestly desires to escape the judgments of God, but in vain. Those that will not be persuaded to fly to the arms of Divine grace, which are now stretched out to receive them, will not be able to flee from the arms of Divine wrath, which will shortly be stretched out to destroy them.