22 Whom have you defied and blasphemed? Against whom have you exalted your voice and lifted up your eyes on high? Against the Holy One of Israel.
*Minor differences ignored. Grouped by changes, with first version listed as example.
The Holy One of Israel - This is a favorite phrase with Isaiah, in whose prophecies it is found 27 times, while it occurs five times only in the rest of Scripture Psalm 71:22; Psalm 78:41; Psalm 89:18; Jeremiah 50:29; Jeremiah 51:5. Its occurrence here is a strong proof - one among many - of the genuineness of the present passage, which is not the composition of the writer of Kings, but an actual prophecy delivered at this time by Isaiah.
Whom hast thou reproached and blasphemed? and against whom hast thou exalted [thy] voice, and lifted up thine eyes on high? [even] (o) against the Holy [One] of Israel.
(o) God counts that as an injury done to him, and will avenge what is done to any of his saints.
*More commentary available at chapter level.