O Jehovah! deliver my soul from the lip of falsehood. David now points out the kind of his affliction, declaring that he was loaded with false accusations. In charging his enemies with lying and falsehood, he asserts his own innocence of the crimes which they slanderously imputed to him. His complaint therefore amounts to this, that as he was conscious of having committed no fault, he was assaulted by the wicked contrary to all law, human and divine, and that they brought him into hatred without his having given them any occasion for such injurious treatment. Deceitful tongues assault good and simple people in two ways' they either circumvent them by wiles and snares, or wound their reputation by calumnies. It is of the second way that the Prophet here complains. Now if David, who was endued with such eminent virtue, and free from every mark of disgrace, and far removed from every wicked action, was yet assailed with contumely, is it to be wondered at if the children of God in the present day labor under false accusations, and that when they have endeavored to conduct themselves uprightly they are yet in reported of? As they have the devil for their enemy, it is indeed impossible for them to escape being loaded with his lies. Yea, we see that slanderous tongues did not spare even the Son of God -- a consideration which should induce us to bear the more patiently our condition, when the wicked traduce us undeservedly; since it is certain that we have here described the common lot of the whole Church.

Deliver my soul, O Lord - My soul is harassed and distressed. Perhaps the meaning also may be, My life is in danger. Or, if it refers to the soul as such, then it means that everything pertaining to his soul was deeply affected by the course which was pursued. He was maligned, slandered, misrepresented, deceived, and he had no comfort or peace.
From lying lips - False, deceitful, slanderous. Compare the notes at Psalm 31:18.
And from a deceitful tongue - From a tongue whose statements cannot be relied on; whose words are deceptive; whose promises are false. David was often called to experience troubles of this sort; and this is a kind of trial which may come upon anyone in a form which he can no more anticipate or prevent than he can the coming of a "mist from the ocean." No man can certainly guard against the influence of falsehood; no man can be sure that all that will be said to him is true; no man can be certain that all the promises made to him - save those made to him by God - will be performed.

Lying lips, and from a deceitful tongue - From a people without faith, without truth, without religion; who sought by lies and calumnies to destroy them.

Deliver my soul, O Lord, from lying lips, and from a deceitful tongue. Not from such lips, and such a tongue of his own, which David abhorred; though every good man desires to be kept from speaking lies and deceit; nor from the company of those who have such lips and tongues, which he was determined should not dwell with him; but from the malignity of them, from being hurt in his character and reputation by them; God can restrain them, and prevent the ill influence of them when he pleases, Psalm 31:20. Such were the lips and tongues of Doeg the Edomite, Psalm 52:2, and of Saul's courtiers, who insinuated to him that David sought his hurt, 1-Samuel 24:9; and of the Scribes and Pharisees, that flattered Christ to his face, and reproached him to the people; and of Judas, that betrayed him with "Hail, master", Matthew 26:49; and of the false witnesses suborned against him; and of false teachers, deceitful workers, that lie in wait to deceive, and, by their good words and fair speeches, do deceive the hearts of the simple; and of antichrist and his followers, who, as they are given up to believe a lie, speak lies in hypocrisy; and of Satan the father of lies, and who is the old serpent, the devil, that deceives the whole world: and to be delivered from the bad effects of such lips and tongues is very desirable.

This is the first of fifteen Psalm (Psalm 120-134) entitled "A Song of Degrees" (Psalm 121:1 --literally, "A song for the degrees"), or ascents. It seems most probable they were designed for the use of the people when going up (compare 1-Kings 12:27-28) to Jerusalem on the festival occasions (Deuteronomy 16:16), three times a year. David appears as the author of four, Solomon of one (Psalm 127:1), and the other ten are anonymous, probably composed after the captivity. In this Psalm the writer acknowledges God's mercy, prays for relief from a malicious foe, whose punishment he anticipates, and then repeats his complaint. (Psalm 120:1-7)
Slander and deceit charged on his foes implies his innocence.
tongue--as in Psalm 52:2, Psalm 52:4.