I exhort Euodias and Syntyche It is an almost universally received opinion that Paul was desirous to settle a quarrel, I know not of what sort, between those two women. While I am not inclined to contend as to this, the words of Paul do not afford ground enough for such a conjecture to satisfy us that it really was so. It appears, from the testimony which he gives in their favor, that they were very excellent women; for he assigns to them so much honor as to call them fellow-soldiers in the gospel [1] . Hence, as their agreement was a matter of great moment [2], and, on the other hand, there would be great danger attendant on their disagreement, he stirs them up particularly to concord. We must take notice, however, that, whenever he speaks of agreement, he adds also the bond of it--in the Lord. For every combination will inevitably be accursed, if apart from the Lord, and, on the other hand, nothing is so disjoined, but that it ought to be reunited in Christ.

Footnotes

1 - "1l les appelle ses compagnes de guerre, d'autant qu'elles ont batail1e auec luy en l'euangile;" -- "He calls them his companions in war, inasmuch as they had struggled hard with him in the gospel."

2 - "C'estoit une chose grandement requise et necessaire qu'elles fussent d'un consentement;" -- "It was a thing greatly requisite and necessary that they should be in a state of agreement."

I beseech Euodias, and beseech Syntyche - These are doubtless the names of females. The name Syntyche is sometimes the name of a man; but, if these persons are referred to in Philippians 4:3, there can be no doubt that they were females. Nothing more is known of them than is here mentioned. It has been commonly supposed that they were deaconesses, who preached the gospel to those of their own sex; but there is no certain evidence of this. All that is known is, that there was some disagreement between them, and the apostle entreats them to be reconciled to each other.
That they be of the same mind - That they be united, or reconciled. Whether the difference related to doctrine, or to something else, we cannot determine from this phrase. The language is such as would properly relate to any difference.
In the Lord - In their Christian walk and plans. They were doubtless professing Christians, and the apostle exhorts them to make the Lord the great object of their affections, and in their regard for him, to bury all their petty differences and animosities.

I beseech Euodias, and beseech Syntyche - These were two pious women, as it is generally supposed, who were deaconesses in the Church at Philippi, and who in some points of doctrine and discipline had disagreed. He exhorts them to be of the same mind, that is, to compose their differences; and, if they could not perfectly agree to think and let think, and to avoid all public opposition, as their dissension would strengthen the hands of the common enemy, and stumble those who were weak. But it is more likely that Euodias was a woman, and Syntyche a man, and probably the husband of Euodias; and that it is Syntyche whom the apostle calls true yokefellow in the next verse.

(2) I beseech Euodias, and beseech Syntyche, that they be of the same mind in the Lord.
(2) He also calls on some by name, partly because they needed private exhortation, and partly also to stir up others to be more prompt and ready.

I beseech Euodias, and beseech Syntyche,.... Two women, who were members of this church at Philippi, and who seem to have been at variance; either with each other, on account of some temporal and civil things, as often is the case of the dear children of God, who fall out by the way; and it becomes a very hard and difficult task to reconcile them, though as here entreated in the most tender and importunate manner to agree: or else with the church, having entertained some sentiments in religion different from it; being drawn aside by false teachers from the simplicity of the Gospel, and their steadfastness in the faith; and this may rather be thought to be the meaning, since the apostle would scarcely take notice of a private difference in so public a manner, and since this exhortation follows so closely the former:
that they be of the same mind in the Lord; either that they agree together, and be reconciled to each other, considering the relation they stood in to one another, and to the Lord; or that they become of the same mind, and embrace the same truths, and profess and maintain the same principles the church did; and so the Arabic version renders it, "that ye entertain one and the same opinion concerning the faith of the Lord".

Let believers be of one mind, and ready to help each other. As the apostle had found the benefit of their assistance, he knew how comfortable it would be to his fellow-labourers to have the help of others. Let us seek to give assurance that our names are written in the book of life. Joy in God is of great consequence in the Christian life; and Christians need to be again and again called to it. It more than outweighs all causes for sorrow. Let their enemies perceive how moderate they were as to outward things, and how composedly they suffered loss and hardships. The day of judgment will soon arrive, with full redemption to believers, and destruction to ungodly men. There is a care of diligence which is our duty, and agrees with a wise forecast and due concern; but there is a care of fear and distrust, which is sin and folly, and only perplexes and distracts the mind. As a remedy against perplexing care, constant prayer is recommended. Not only stated times for prayer, but in every thing by prayer. We must join thanksgivings with prayers and supplications; not only seek supplies of good, but own the mercies we have received. God needs not to be told our wants or desires; he knows them better than we do; but he will have us show that we value the mercy, and feel our dependence on him. The peace of God, the comfortable sense of being reconciled to God, and having a part in his favour, and the hope of the heavenly blessedness, are a greater good than can be fully expressed. This peace will keep our hearts and minds through Christ Jesus; it will keep us from sinning under troubles, and from sinking under them; keep us calm and with inward satisfaction. Believers are to get and to keep a good name; a name for good things with God and good men. We should walk in all the ways of virtue, and abide therein; then, whether our praise is of men or not, it will be of God. The apostle is for an example. His doctrine and life agreed together. The way to have the God of peace with us, is to keep close to our duty. All our privileges and salvation arise in the free mercy of God; yet the enjoyment of them depends on our sincere and holy conduct. These are works of God, pertaining to God, and to him only are they to be ascribed, and to no other, neither men, words, nor deeds.

Euodia and Syntyche were two women who seem to have been at variance; probably deaconesses of the church. He repeats, "I beseech," as if he would admonish each separately, and with the utmost impartiality.
in the Lord--the true element of Christian union; for those "in the Lord" by faith to be at variance, is an utter inconsistency.

I beseech Euodias and beseech Syntyche. Two good women of Philippi, who had apparently been estranged. Women were prominent in the founding of the Philippian church; Lydia was the first convert, and her house was a home of the missionaries. Observe the repetition of the word "beseech." It gives it special emphasis.
I intreat thee, true yoke-fellow. Some very dear brother who had been a fellow-laborer of Paul. The term is applied to the relation of husbands and wives, and to that of very intimate friends. The one addressed must have been a companion of toils and sufferings. Some have thought that Silas, associated with him in suffering at Philippi (see Acts, chapter 16), is meant, and that he was at Philippi when this letter was sent, but this is not certain.
Help those women. As Euodias and Syntyche have just been named, they are those meant. They had zealously aided his labors at Philippi.
With Clement also. The Clement named is thought to be the same who was later a bishop at Rome, and the author of certain extant Epistles to the Corinthians. The name, however, was so common that this is uncertain.
In the book of life. Compare Revelation 3:5; Revelation 13:8; Revelation 17:8; Revelation 20:12. Those are held to have their names in the book of life who are enrolled as the children of God.

I beseech - He repeats this twice, as if speaking to each face to face, and that with the utmost tenderness.