But he answered and said unto him that told him, Who is my mother? and who are my brethren?

But he answering him that told him, said: Who is my mother, and who are my brethren?

But he answering said to him that spoke to him, Who is my mother, and who are my brethren?

But he in answer said to him who gave the news, Who is my mother and who are my brothers?

But responding to the one speaking to him, he said, "Which one is my mother, and who are my brothers?"

Who is my mother? These words were unquestionably intended to reprove Mary's eagerness, and she certainly acted improperly in attempting to interrupt the progress of his discourse. At the same time, by disparaging the relationship of flesh and blood, our Lord teaches a very useful doctrine; for he admits all his disciples and all believers to the same honorable rank, as if they were his nearest relatives, or rather he places them in the room of his mother and brethren Now this statement is closely connected with the office of Christ; for he tells us that he has been given, not to a small number of individuals, but to all the godly, who are united in one body with him by faith. He tells us also, that there is no tie of relationship more sacred than spiritual relationship, because we ought not to think of him according to the flesh, but according to the power of his Spirit which he has received from the Father to renew men, so that those who are by nature the polluted and accursed seed of Abraham begin to be by grace the holy and heavenly sons of God. In like manner, Paul affirms that to know Christ after the flesh is not to know him properly, (2-Corinthians 5:16,) because we ought rather to consider that renovation of the world, which far exceeds human power, and which takes place when he forms us anew by his Spirit to the image of God. To sum up the whole, this passage, first, teaches us to behold Christ with the eyes of faith; and, secondly, it informs us, that every one who is regenerated by the Spirit, and gives himself up entirely to God for true justification, is thus admitted to the closest union with Christ, and becomes one with him.

Who is my mother? - There was no want of affection or respect in Jesus toward his mother, as is proved by his whole life.
See especially Luke 2:51, and John 19:25-27. This question was asked merely to "fix the attention" of the hearers and to prepare them for the answer - that is, to show them who sustained toward him the nearest and most tender relation. To do this he pointed to his disciples. Dear and tender as were the ties which bound him to his mother and brethren, yet those which bound him to his disciples were more tender and sacred. How great was his love for his disciples, when it was more than even that for his mother! And what a bright illustration of his own doctrine, that we ought to forsake father, and mother and friends, and houses, and lands, to be his followers!
Remarks On Matthew 12
1. Our Saviour has taught us the right use of the Sabbath, Matthew 12:1-13. His conduct was an explanation of the meaning of the fourth commandment. By his example we may learn what may be done. He himself performed only those works on the Sabbath which were strictly necessary for life, and those which tended to benefit the poor, the afflicted, and needy. Whatever work is done on the Sabbath that is not for these ends must be wrong. All labor that can as well be done on another day all which is not for the support of life, or to aid the ignorant, poor, and sick. must be wrong. This example justifies teaching the ignorant, supplying the wants of the poor, instructing children in the precepts of religion, teaching those to read in Sunday schools who have no other opportunity for learning, and visiting the sick, when we go not for formality, or "to save time on some other day," but to do them good.
2. The Sabbath is of vast service to mankind. It was made for man - not for man to violate or profane, or to be a day of mere idleness, but to improve to his spiritual and eternal good. Where people are employed through "six" days in worldly occupations, it is kind toward them to give them one day particularly to prepare for eternity. Where there is no Sabbath there is no religion. This truth, from the history of the world, will bear to be recorded in letters of gold - "that true religion will exist among men only when they strictly observe the Sabbath." They, therefore, who do most to promote the observance of the Sabbath, are doing most for religion and the welfare of man. In this respect Sunday school teachers may do more, perhaps, than all the world besides for the best interests of the world.
3. In the conduct of Christ Matthew 12:14-15 we have an illustration of the nature of Christian prudence. He did not throw himself needlessly into danger. He did not remain to provoke opposition. He felt that his time was not come, and that his life, by a prudent course, should be preserved. He therefore withdrew. Religion requires us to sacrifice our lives rather than deny the Saviour. To throw our lives away when, with good conscience, they might be preserved, is self-murder.
4. The rejection of the gospel in one place is often the occasion of its being received elsewhere, Matthew 12:15. People may reject it to their own destruction; but somewhere it "will" be preached, and will be the power of God unto salvation. The wicked cannot drive it out of the world. They only secure their own ruin, and, against their will, benefit and save others. To reject it is like turning a beautiful and fertilizing stream from a man's own land. He does not, he cannot dry it up. "It will flow somewhere else." He injures himself and perhaps benefits multitudes. People never commit so great foolishness and wickedness, and so completely fail in what they aim at, as in rejecting the gospel. A man, hating the light of the sun, might get into a cave or dungeon, and be in total darkness; but the sun will continue to shine, and millions, in spite of him, will be benefited by it. So it is with the gospel.
5. Christ was mild, quiet, retiring not clamorous or noisy, Matthew 12:19. So is all religion. There is no piety in noise; if there was, then thunder and artillery would be piety. Confusion and discord are not religion. Loud words and shouting are not religion. Religion is love, reverence, fear, holiness, a deep and awful regard for the presence of God, profound apprehensions of the solemnities of eternity, imitation of the Saviour. It is still. It is full of awe - an awe too great to strive, or cry, or lift up the voice in the streets. If people ever should be overawed and filled with emotions "repressing" noise and clamor, it should be when they approach "the great God."
6. The feeble may trust to Jesus, Matthew 12:20. A child of any age, an ignorant person, the poorest man, may come, and he shall in nowise be east out. It is a sense of our weakness that Jesus seeks. Where that is "he" will strengthen us, and we shall not fail.
7. Grace will not be extinguished, Matthew 12:20. Jesus, where he finds it in the feeblest degree, will not destroy it. He will cherish it. He will kindle it to a flame. It will burn brighter and brighter, until it "glows like that of the pure spirits above."
8. People are greatly prone to ascribe all religion to the devil, Matthew 12:24. Anything that is unusual, anything that confounds them, anything that troubles their consciences, they ascribe to fanaticism, overheated zeal, and Satan. It has always been so. It is sometimes an easy way to stifle their own convictions, and to bring religion into contempt. "Somehow or other," like the Pharisees, infidels must account for revivals of religion, for striking instances of conversion, and for the great and undeniable effects which the gospel produces. How easy to say that it is "delusions," and that it is the work of the devil! How easy to show at once the terrible opposition of their own hearts to God, and to boast themselves in their own wisdom, in having found a cause so simple for all the effects which religion produces in the world! How much pains, also, men will take to secure their own perdition, rather than to admit it to be possible that Christianity is true!
9. We see the danger of blasphemy - the danger of trifling with the influences of the Holy Spirit, Matthew 12:31-32. Even if we do not commit the unpardonable sin, yet we see that all trifling with the Holy Spirit is a sin very near to God, and attended with infinite danger. He that "laughs away" the thoughts of death and eternity; he that seeks the society of the frivolous and trifling, or of the sensual and profane, for the express purpose of driving away these thoughts; and he that struggles directly against his convictions, and is resolved that he will not submit to God, may be, for aught he knows, making his damnation sure. Why should God "ever" return when a man has "once" rejected the gospel? Who would be to blame if the sinner is then lost? Assuredly not God. None but himself. Children sometimes do this. Then is the time, the very time, when they should begin to love God and Jesus Christ. Then the Spirit also strives. Many "have then" given their hearts to him and become Christians. Many more might have done so, if they had not grieved away the Spirit of God.
10. We see the danger of rejecting Christ, Matthew 12:38-42. All past ages, all the wicked and the good, the foolish and the wise, will rise up in the day of judgment, and condemn us, if we do not believe the gospel. No people, heretofore, have seen so much light as we do in this age. And no people can be so awfully condemned as those who, in a land of light, of Sundays and Sunday schools, reject Christ and go to hell. Among the 120,000 children of Nineveh Jonah 4:11 there was not one single Sunday school. There was no one to tell them of God and the Saviour. They have died and gone to judgment. Children now living will die also, and go to meet them in the day of judgment. How will they condemn the children of this age, if they do not love the Lord Jesus Christ!
11. Sinners, when awakened, if they grieve away the Spirit of God, become worse than before, Matthew 12:43-45. They are never as they were before. Their hearts are harder, their consciences are more seared, they have a more bitter hatred of religious people, and they plunge deeper and deeper into sin. Seven devils often dwell where one did, and God gives the man over to blindness of mind and hardness of heart. This shows, also, the great guilt and danger of grieving the Holy Spirit.
12. We see the love of Christ for his followers, Matthew 12:46-50. Much as he loved his mother, yet he loved his disciples more. He still loves them. He will always love them. His heart is full of affection for them. And though poor, and despised, and unknown to the rich and mighty, yet to Jesus they are dearer than mother, and sisters, and brothers.

Who is my mother? and who are my brethren? - The reason of this seeming disregard of his relatives was this: they came to seize upon him, for they thought he was distracted. See Mark 3:33.

But he answered and said unto him that told him,.... Of his mother and brethren being without doors, desiring, and waiting to speak to him,
Who is my mother? and who are my brethren? These questions are put, not as if he himself was ignorant who were his mother or his brethren; or as suggesting as if he had none; or as denying that these were in such a relation to him; or as casting any slight upon them; or as intending to teach men disrespect to parents and kindred, according to the flesh; but as displeased with the man, or men, for interrupting him in his work; and to let them know, that the business of his heavenly Father was preferred by him to any his natural relations could have with him; and that he might have an opportunity of pointing out who were his relations in a spiritual sense.

Who is my mother, and my brethren? An allusion to his Divine character, which lifted him above the ordinary ties of the flesh.
Behold my mother and my brethren. His real relatives are those bound to him by spiritual ties.

And he answering, said - Our Lord's knowing why they came, sufficiently justifies his seeming disregard of them.