Sanctuaries - The holy places in the tabernacle and the temple (Psalm 68:35. Compare Psalm 74:7).
I will not smell the savor - See Leviticus 1:9.

And I will make your cities waste, and bring your sanctuaries unto desolation, and I (p) will not smell the savour of your sweet odours.
(p) I will not accept your sacrifices.

I will make your cities waste,.... By suffering the enemy to besiege them, enter into them, and plunder them, and destroy the houses in them, and reduce them to the most desolate condition, as Jerusalem, their metropolis, was more than once:
and bring your sanctuaries unto desolation; the temple, so called from the several apartments in it, the court, the holy place, and the most holy; or rather both sanctuaries or temples are intended, the first built by Solomon, and destroyed by Nebuchadnezzar; the second rebuilt by Zerubbabel, and adorned by Herod, and reduced to ashes by Titus Vespasian: the Jews understand this of their synagogues, which were many both in Jerusalem, and in other parts of their country, but cannot be intended, since it follows:
and I will not smell the savour of your sweet odours: of their incense offered on the altar of incense; or the savour of their offerings, as the Targum of Jonathan, of their burnt offerings, and the fat of their other offerings burnt on the altar of burnt offering; signifying, that these would not be acceptable to him, or he smell a savour of rest in them; see Genesis 8:21; now these were only offered in the temple, not in synagogues.

I will make your cities waste--This destruction of its numerous and flourishing cities, which was brought upon Judea through the sins of Israel, took place by the forced removal of the people during, and long after, the captivity. But it is realized to a far greater extent now.
bring your sanctuaries unto desolation, and I will not smell the savour of your sweet odours--the tabernacle and temple, as is evident from the tenor of the subsequent clause, in which God announces that He will not accept or regard their sacrifices.

Their towns and their sanctuaries He would destroy, because He took no pleasure in their sacrificial worship. מקדּשׁים are the holy things of the worship of Jehovah, the tabernacle and temple, with their altars and the rest of their holy furniture, as in Ps. 68:36; Psalm 74:7. ניחח ריח (Leviticus 1:9) is the odour of the sacrifice; and ריח, to smell, an anthropomorphic designation of divine satisfaction (cf. Amos 5:21; Isaiah 11:3).

Sanctuaries - God's sanctuary, called sanctuaries here, as also Psalm 73:17, Psalm 74:7; Jeremiah 51:51; Ezekiel 28:18, because there were divers apartments in it, each of which was a sanctuary, or, which is all one, an holy place, as they are severally called. And yours emphatically, not mine, for I disown and abhor it, and all the services you do in it, because you have defiled it. I will not smell - Not own or accept them. Your sweet odours - Either of the incense, or of your sacrifices, which when offered with faith and obedience, are sweet and acceptable to me.