Is not my help in me? - This would be better rendered in an affirmative manner, or as an exclamation. The interrogative form of the previous verses need not be continued in this. The sense is, "alas! there is no help in me!" That is, "I have no strength; I must give up under these sorrows in despair." So it is rendered by Jerome, Rosenmuller, Good, Noyes, and others.
And is wisdom quite driven from me? - This, also, should be read as an affirmation, "deliverance is driven from me." The word rendered wisdom (תשׁיה tûshı̂yâh) means properly a setting upright; then help, deliverance; and then purpose, enterprise; see the notes at Job 5:12. Here it means that all hope of deliverance had fled, and that he was sinking in despair.

Is not my help in me? - My help is all in myself; and, alas! that is perfect weakness: and my subsistence, תושיה tushiyah, all that is real, stable, and permanent, is driven quite from me. My friends have forsaken me, and I am abandoned to myself; my property is all taken away, and I have no resources left. I believe Job neither said, nor intended to say, as some interpreters have it, Reason is utterly driven from me. Surely there is no mark in this chapter of his being deranged, or at all impaired in his intellect.

[Is] not my (i) help in me? and is wisdom driven quite from me?
(i) Have I not sought to help myself as much as was possible?

Is my help in me?.... Or "my defence" (y), as some; is it not in my power to defend myself against the calumnies and reproaches cast upon me? it is; and, though one have no help in myself to bear my burdens, or extricate myself out of my difficulties, yet I have the testimony of a good conscience within me, that supports me; and I have the strength and force of reason and argument on my side, to defend me against all objectors:
and is wisdom driven from me? either sound doctrine, the law (z), or, rather, the Gospel, the wisdom of God in a mystery, revealed in the words of the Holy One before mentioned; or wisdom in the hidden part, the fear of God, which is wisdom, true grace in the heart, which, when once implanted, can never be driven out; or natural reason and understanding, of which he was not bereaved; for, though his body was thus sorely afflicted, he retained his reasoning and intellectual faculties. The words, in connection with the former, may be read, "what, if help is not with me, is wisdom also driven quite from me?" (a) does it follow, because I am not able to help myself out of this afflicted and distressed condition in which I am, that I am deprived of my reason? or be it that I am such a weak impotent creature, and even distracted, as you take me to be, should I not then rather be pitied than insulted? so some (b) connect the words following.
(y) "defensio mea penes me", Junius et Tremellius, Piscator. (z) "lex", Mercerus; so Peritsol. (a) So Cocceius and Schultens. (b) So De Dieu.

Is not my help in me?--The interrogation is better omitted. "There is no help in me!" For "wisdom," "deliverance" is a better rendering. "And deliverance is driven quite from me."

What, &c. - If my outward condition be helpless and hopeless? Have I therefore lost my understanding, cannot I judge whether it is more desirable for me to live or to die, whether I be an hypocrite or no, whether your words have truth and weight in them; whether you take the right method in dealing with me?