Lift up your eyes on high - Direct your eyes toward heaven, and in the contemplation of the wonders of the starry world, and of God's power there, learn the evidence of his ability to destroy his foes and to save his friends. Lowth connects this verse with the former, and renders it:
'Saith the Holy One,
Lift up your eyes on high.'
The words 'on high' here are evidently synonymous with heaven, and refer to the starry worlds. The design of the passage is to convince them of the folly of idolatry, and of the power and majesty, of the true God. It is proof of man's elevated nature that he can thus look upward, and trace the evidences of the power and wisdom of God in the heavens; that he can raise his eyes and thoughts above the earth, and fix his attention on the works of God in distant worlds; and in the number, the order, the greatness, and the harmony of the heavenly bodies, trace the proofs of the infinite greatness and the wisdom of God. This thought was most beautifully expressed by one of the ancient poets.
Pronaque cum spectent animalia caetera terram;
Os homini sublime dedit: ccelumque tueri,
Jussit et erectos ad sidera tollere vultus.
Ovid, Met. i. 84-86.
In the Scriptures, God not unfrequently appeals to the starry heavens in proof of his existence and perfections, and as the most sublime exhibition of his greatness and power (see Psalm 19:1-6). And it may be remarked, that this argument is one that increases in strength, in the view of people, from age to age, just in proportion to the advances which are made in the science of astronomy. It is now far more striking than it was in the times of Isaiah; and, indeed, the discoveries in astronomical science in modern times have given a beauty and power to this argument which could have been but imperfectly understood in the times of the prophets. The argument is one that accumulates with every new discovery in astronomy; but is one - such is the vastness and beauty of the system of the universe - which can be contemplated in its fall power only amidst the more sublime contemplations of eternity. Those who are disposed to contemplate this argument more fully, may find it presented with great eloquence and beauty in Dr. Chalmers' Astronomical Discourses, and in Dick's Christian Philosopher.
Who hath created these things - These heavens. This is the first evidence of the power of God in the contemplation of the heavens, that God is their Creator. The other demonstrations referred to are the fact, that he brings out their armies as if they were a marshalled host, and understands and calls all their names.
That bringeth out their hosts - Their armies, for so the word 'hosts' means (see the note at Isaiah 1:9). The word here alludes to the fact that the heavenly bodies seem to be marshalled, or regularly arrayed as an array; that they keep their place, preserve their order, and are apparently led on from the east to the west, like a vast army under a mighty leader:
Canst thou bring forth Mazzaroth in his season?
Or canst thou guide Arcturus with his sons?
Job 38:32
By number - As if he had numbered, or named them; as a military commander would call forth his armies in their proper order, and have them so numbered and enrolled in the various divisions, that he can command them with ease.
He calleth them all by names - This idea is also taken from a military leader, who would know the names of the individuals that composed his army. In smaller divisions of an army, this could of course be done; but the idea is, that God is intimately acquainted with all the hosts of stars; that though their numbers appear to us so great, yet he is acquainted with each one individually, and has that knowledge of it which we have of a person or object which we recognize by a name. It is said of Cyrus, that he was acquainted by name with every individual that composed his vast army. The practice of giving names to the stars of heaven was early, and is known to have been originated by the Chaldeans. Intimations of this custom we have not unfrequently in the Scriptures, as far back as the time of Job:
Which maketh Arcturus, and Orion, and Pleiades,
And the chambers of the south.
Job 9:9
Canst thou bind the sweet influences of Pleiades?
Or loose the bands of Orion?
Canst thou bring forth Mazzaroth in his season?
Or canst thou guide Arcturus with his sons?

Mazzaroth in his season? - This is generally understood to mean the signs of the zodiac. מזרות Mazzaroth, according to Parkhurst, comes from מזר mazar, to corrupt; and he supposes it to mean that pestilential wind in Arabia, called simoom, the season of which is the summer heats.

Canst thou bring forth (s) Mazzaroth in his season? or canst thou guide (t) Arcturus with his sons?
(s) Certain stars so called, some think they were the twelve signs.
(t) The north star with those that are about him.

Canst thou bring forth Mazzaroth in his season?.... Which are thought to be the same with "the chambers of the south", Job 9:9; the southern pole (m) with its stars, signified by chambers, because hidden from our sight in this part of the globe; and here by Mazzaroth, from, "nazar", to separate, because separated and at a distance from us; some think (n) the twelve signs of the Zodiac are meant, each of which are brought forth in their season, not by men, but by the Lord; see Isaiah 40:26;
or canst thou guide Arcturus with his sons? a constellation of many stars called its sons, of which see Job 9:9. Schmidt conjectures that Jupiter and his satellites are meant; but rather what we call the greater and lesser Bear, in the tail of which is the north pole star, the guide of mariners, said (o) to be found out by Thales, by which the Phoenicians sailed, but is not to be guided by men; this, constellation is fancied to be in the form of a wain or wagon, and is called Charles's wain; could this be admitted, there might be thought to be an allusion to it (p), and the sense be, canst thou guide and lead this constellation, as a wagon or team of horses can be guided and led? stars have their courses, Judges 5:20; but are not steered, guided, and directed by men, but by the Lord himself.
(m) David de Pomis, Lexic. fol. 77. 3. (n) Vatablus, Codurcus, Schultens; so Suidas in voce (o) Callimachus apud Laert. Vit. Thalet. p. 16. (p) Vid. Hinckelman. Praefat. ad Alkoran. p. 29, 30.

Canst thou bring forth from their places or houses (Mazzaloth, 2-Kings 23:5, Margin; to which Mazzaroth here is equivalent) into the sky the signs of the Zodiac at their respective seasons--the twelve lodgings in which the sun successively stays, or appears, in the sky?
Arcturus--Ursa Major.
his sons?--the three stars in his tail. Canst thou make them appear in the sky? (Job 9:9). The great and less Bear are called by the Arabs "Daughters of the Bier," the quadrangle being the bier, the three others the mourners.

Bring forth - Canst thou make the stars in the southern signs arise and appear? Arcturus - Those in the northern. His sons - The lesser stars, which are placed round about them; and attend upon them, as children upon their parents.