Thou shalt seek them. That is, if thou seek them; for enemies are not sought, when they have been put to flight; and therefore I think that this future ought to be rendered as a subjunctive, "If thou seek them, thou shalt not find them; for they shall be destroyed and reduced to nothing." Here it ought to be observed that he describes two kinds of enemies, one, of those who attack us by open violence, the other, of those who attack us by words, that is, who tear us by slanders, curses, and reproaches, and who, as if they were defending a righteous cause, carry on various controversies with us, and summon us to courts of justice, and often accuse us of those crimes of which they have been guilty. But these are the stratagems of Satan, and we need not wonder that they who are his servants imitate their lord and master. The Prophet therefore mentions armed enemies who violently fight against the Church, and next brings forward wranglers, who annoy the Church by deceit and slander, and by false pretense of justice. We need not wonder, therefore, that such accusations are directed against us, and we ought not to think it strange, if many unprincipled men in the present day sell themselves to Antichrist to slander us; for the same thing happened formerly to prophets and other servants of God.

Thou shalt seek them - This denotes that it would be impossible to find them, for they should cease to exist. The whole verse, with the verse following, is emphatic, repeating in varied terms what was said before, and meaning that their foes should be entirely destroyed.

Thou shalt seek them, and shalt not (l) find them, [even] them that contended with thee: they that war against thee shall be as nothing, and as a thing of naught.
(l) Because they will be destroyed.

They not existing, or being fled into holes and corners, to rocks and mountains, to hide themselves from the wrath of the Lamb, Revelation 6:15,
even them that contended with thee; or, "the men of thy contention" (p); who contended with them, not by words and arguments, but by severe persecutions, striving thereby to hinder the progress of the Gospel, and to root Christianity out of the world:
they that war against thee shall be as nothing, and as a thing of nought: or, "the men of thy war" (q); that proclaimed and carried on war against the Christians, in order to destroy them utterly; yet they, and all their efforts, came to nothing, the Gospel prevailed, and Paganism was utterly abolished; which came to pass in Constantine's time, at the opening of the sixth seal, Revelation 6:12 which is a proper comment on this text.
(p) "viros jurgii tui", Montanus. (q) "viri belli tui", Vatablus; "pugnae tuae", Montanus.

seek . . . and . . . not find--said of one so utterly put out of the way that not a trace of him can be found (Psalm 37:36).
thing of naught--shall utterly perish.