Come up again - To the upper room, Acts 20:8.
And had broken bread, and eaten - Had taken refreshment. As this is spoken of Paul only, it is evidently distinguished from the celebration of the Lord's Supper.

Had broken bread - Had taken some refreshment, in order to their journey.
And talked a long while - Ὁμιλησας, Having familiarly conversed, for this is the import of the word, which is very different from the διελεγετο, of the seventh verse, and the διαλεγομενου, of the ninth; which imply solemn, grave discourse.

When he therefore was come up again,.... Into the upper room, where he was before, and where the disciples were gathered together:
and had broken bread and eaten; administered the Lord's supper, and also eat for his bodily refreshment:
and talked a long while: about the ordinance and the doctrines of the Gospel, and spiritual experience, and such like divine things:
even till break of day; not knowing when to leave off:
so he departed; without taking any rest; though before he departed, what follows was done; it was at this time he left his cloak, books, and parchments here, 2-Timothy 4:13.

broken bread and eaten--with what a mixture of awe and joy after such an occurrence! "And eaten"--denoting a common repast, as distinguished from the breaking of the eucharistic bread.
and talked a long while, even till break of day--How lifelike this record of dear Christian fellowship, as free and gladsome as it was solemn! (See Ecclesiastes 9:7).

So departed - Without taking any rest at all.