For in this we both labor and suffer reproaches This is an anticipation by which he solves that question, "Are not believers the most miserable of all men, because they are oppressed by tribulations of every kind?" In order to show, therefore, that their condition must not be judged from outward appearance, he distinguishes them from others, first in the cause, and next in the result. Hence it follows, that they lose nothing of the promises which he has mentioned, when they are tried by adversity. The sum is, that believers are not miserable in afflictions, because a good conscience supports them, and a blessed and joyful end awaits them. Now, since the happiness of the present life consists chiefly of two parts, honor and conveniences, he contrasts them within two evils, toils and reproach, meaning by the former words, inconveniences and annoyances of every kind, such as poverty, cold, nakedness, hunger, banishments, spoliations, imprisonments, scourgings, and other persecutions. We have hope fixed on the living God This consolation refers to the cause; for so far are we from being miserable, when we suffer on account of righteousness, that it is rather a just ground of thanksgiving. Besides, our afflictions are accompanied by hope in the living God, and, what is more, hope may be regarded as the foundation; but it never maketh ashamed, (Romans 5:5,) and therefore everything that happens to the godly ought to be reckoned a gain. Who is the Savior [1] This is the second consolation, though it depends on the former; for the deliverance of which he speaks may be viewed as the fruit of hope. To make this more clear, it ought to be understood that this is an argument drawn from the less to the greater; for the word soter [2] is here a general term, and denotes one who defends and preserves. He means that the kindness of God extends to all men. And if there is no man who does not feel the goodness of God towards him, and who is not a partaker of it, how much more shall it be experienced by the godly, who hope in him? Will he not take peculiar care in them? Will he not more freely pour out his bounty on them? In a word, will he not, in every respect, keep them safe to the end?

Footnotes

1 - "The word Savior is not here taken in what we call its proper and strict meaning, in regard to the eternal salvation which God promises to his elect, but it is taken for one who delivers and protects. Thus we see that even unbelievers are protected by God, as it is said (Matthew 5:46) that "he maketh his sun to shine on the good and the bad;" and we see that all are fed by his goodness, that all are delivered from many dangers. In this sense he is called "the Savior of all men," not in regard to the spiritual salvation of their souls, but because he supports all his creatures. In this way, therefore, our Lord is the Savior of all men, that is, his goodness extends to the most wicked, who are estranged from him, and who do not deserve to have any intercourse with him, who ought to have been struck off from the number of the creatures of God and destroyed; and yet we see how God hitherto extends his grace to them; for the life which he gives to them is a testimony of his goodness. Since, therefore God shows such favor towards those who are strangers to him, how shall it be with us who are members of his household? Not that we are better or more excellent than those whom we see to be cast off by him, but the whole proceeds from his mercy and free grace, that he is reconciled to us through our Lord Jesus Christ, since he hath called us to the knowledge of the gospel, and then confirms us, and seals his bounty toward us, so that we ought to be convinced that he reckons us to be his children. Since, therefore, we see that he nourishes those who are estranged from him, let us go and hide ourselves under his wings; for, having taken us under his protection, he has declared that he will show himself to be a Father toward us." -- Fr. Ser.

2 - "Le mot Grec que nous traduisons Sauveur." -- "The Greek word which we translate Savior."

For therefore we both labour and suffer reproach - In making this truth known, that all might be saved, or that salvation was offered to all. The "labor" was chiefly experienced in carrying this intelligence abroad among the Gentiles; the "reproach" arose chiefly from the Jews for doing it.
Because we trust in the living God - This does not mean, as our translation would seem to imply, that he labored and suffered "because" he confided in God, or that this was the "reason" of his sufferings, but rather that this trust in the living God was his "support" in these labors and trials. "We labor and suffer reproach, for we have hope in God. Through him we look for salvation. We believe that he has made this known to people, and believing this, we labor earnestly to make it known, even though it be attended with reproaches." The sentiment is, that the belief that God has revealed a plan of salvation for all people, and invites all people to be saved, will make his friends willing to "labor" to make this known, though it be attended with reproaches.
Who is the Saviour of all men - This must be understood as denoting that he is the Saviour of all people in some sense which differs from what is immediately affirmed - "especially of those that believe." There is something pertaining to "them" in regard to salvation which does not pertain to "all men." It cannot mean that he brings all people to heaven, "especially" those who believe - for this would be nonsense. And if he brings all people actually to heaven, how can it be "especially" true that he does this in regard to those who believe? Does it mean that he saves others "without" believing? But this would be contrary to the uniform doctrine of the Scriptures; see Mark 16:16. When, therefore, it is said that he "is the Saviour of 'all' people, 'especially' of those who believe," it must mean that there is a sense in which it is true that he may be called the Saviour of all people, while, at the same time, it is "actually" true that those only are saved who believe. This may be true in two respects:
(1) As he is the "Preserver" of people Job 7:20, for in this sense he may be said to "save" them from famine, and war, and peril - keeping them from day to day; compare Psalm 107:28;
(2) as he has "provided" salvation for all people. He is thus their Saviour - and may be called the common Saviour of all; that is, he has confined the offer of salvation to no one class of people; he has not limited the atonement to one division of the human race; and he actually saves all who are willing to be saved by him.
(See supplementary note on 2-Corinthians 5:21. This passage however is not regarded a proof text now on the extent of the atonement, as the fair rendering of σωτήρ sōtēr is "Preserver." Dr. Wardlaw has accordingly excluded it in his recent work.)
Specially of those that believe - This is evidently designed to limit the previous remark. If it had been left there, it might have been inferred that he would "actually save" all people. But the apostle held no such doctrine, and he here teaches that salvation is "actually" limited to those who believe. This is the speciality or the uniqueness in the salvation of those who actually reach heaven, that they are "believers;" see the notes on Mark 16:16. All people, therefore, do not enter heaven, unless all people have faith. But is this so? What evidence is there that the great mass of mankind die believing on the Son of God?

For therefore we both labor - This verse was necessary to explain what he had before said; and here he shows that his meaning was not that the followers of God should enjoy worldly prosperity and exemption from natural evils; for, said he, it is because we exercise ourselves to godliness that we have both labor and reproach, and we have these because we trust In the living God: but still we have mental happiness, and all that is necessary for our passage through life; for in the midst of persecutions and afflictions we have the peace of God that passeth knowledge, and have all our crosses and sufferings so sanctified to us that we consider them in the number of our blessings.
Who is the Savior of all men - Who has provided salvation for the whole human race, and has freely offered it to them in his word and by his Spirit.
Specially of those that believe - What God intends for All, he actually gives to them that believe in Christ, who died for the sins of the world, and tasted death for every man. As all have been purchased by his blood so all may believe; and consequently all may be saved. Those that perish, perish through their own fault.

For therefore we both labour,.... Not in the word and doctrine, though they did; nor in the exercise of internal godliness, though there is a work in faith, and a labour in love; nor with their own hands, at their trades and business, to support themselves, and others; but by enduring hardships and afflictions, as stripes, imprisonment, weariness, pain, watchings, fastings, hunger, thirst, cold, and nakedness; see 2-Corinthians 11:23.
And suffer reproach; with patience and cheerfulness. The Alexandrian copy, and another manuscript, read, "we strive"; or contend even to an agony, combating with sin, Satan, and the world, with profane men, and with false teachers; and to all this they were animated by the promises made to godliness; and therefore they showed it by their practices, or rather by their sufferings, that they believed it to be a true and faithful saying; and which is further conferred by what follows:
because we trust in the living God; for the accomplishment of the said promises, who has power, and therefore can, and is faithful, and therefore will, make good what he has promised; and since it is life he has promised, faith is the more encouraged to trust in him, since he is the living God, in opposition to, and distinction from, lifeless idols; he has life in himself, essentially, originally, and independently, and is the author and giver of life, natural, spiritual, and eternal, unto others. Wherefore there is good reason to trust in him for the fulfilling of the promises of the present and future life, made unto godliness.
Who is the Saviour of all men; in a providential way, giving them being and breath, upholding them in their beings, preserving their lives, and indulging them with the blessings and mercies of life; for that he is the Saviour of all men, with a spiritual and everlasting salvation, is not true in fact.
Specially of those that believe; whom though he saves with an eternal salvation; yet not of this, but of a temporal salvation, are the words to be understood: or as there is a general providence, which attends all mankind, there is a special one which relates to the elect of God; these are regarded in Providence, and are particularly saved and preserved before conversion, in order to be called; and after conversion, after they are brought to believe in Christ, they are preserved from many enemies, and are delivered out of many afflictions and temptations; and are the peculiar care and darlings of providence, being to God as the apple of his eye: and there is a great deal of reason to believe this, for if he is the Saviour of all men, then much more of them who are of more worth, value, and esteem with him, than all the world beside; and if they are saved by him with the greater salvation, then much more with the less; and if he the common Saviour of all men, and especially of saints, whom he saves both ways, then there is great reason to trust in him for the fulfilment of the promises of life, temporal and eternal, made to godliness, and godly persons. This epithet of God seems to be taken out of Psalm 17:7 where he is called , "the Saviour of them that trust", or believe.

therefore--Greek, "with a view to this." The reason why "we both ('both' is omitted in the oldest manuscripts) labor (endure hardship) and suffer reproach (some oldest manuscripts read 'strive') is because we have rested, and do rest our hope, on the living (and therefore, life-giving, 1-Timothy 4:8) God."
Saviour--even in this life (1-Timothy 4:8).
specially of those that believe--Their "labor and reproach" are not inconsistent with their having from the living God, their Saviour, even the present life (Mark 10:30, "a hundred fold now in this time . . . with persecutions"), much more the life to come. If God is in a sense "Saviour" of unbelievers (1-Timothy 2:4, that is, is willing to be so everlastingly, and is temporally here their Preserver and Benefactor), much more of believers. He is the Saviour of all men potentially (1-Timothy 1:15); of believers alone effectually.

For therefore. On account of the eternal life which godliness insures.
We labor and suffer reproach. Compare 2-Corinthians 11:21-27.
These things. Especially what has been embraced in 1-Timothy 4:8-10.

Therefore - Animated by this promise. We both labour and suffer reproach - We regard neither pleasure, ease, nor honour. Because we trust - For this very thing the world will hate us. In the living God - Who will give us the life he has promised. Who is the Saviour of all men - Preserving them in this life, and willing to save them eternally. But especially - In a more eminent manner. Of them that believe - And so are saved everlastingly.