But now - Having no further opportunity in these regions to preach to those who have never heard the gospel.
In these parts - In the regions before specified. He had gone over them, had established churches, had left them in the care of elders Acts 20:17, and was now prepared to penetrate into some new region, and lay the foundation of other churches.
And having a great desire - See Romans 1:9-13.

But - having no more place in these parts - Having nothing farther at present that I can do - for τοπον εχειν signifies not merely to have a place of residence, or the like, but convenience, opportunity; which is a frequent meaning of the phrase among the best Greek writers - having no large place or city, where Christianity has not yet been planted, in which I can introduce the Gospel. The apostle was then at Corinth; and having evangelized all those parts, he had no opportunity of breaking up any new ground.

But now having no more place in these parts,.... Not because persecution was too hot for him, and therefore could not stay any longer, for this was what he expected everywhere; nor did it discourage him in his work, for he took pleasure in enduring it for the sake of Christ and his Gospel; but because he had fully preached the Gospel from Jerusalem, in his circuit to Illyricum, had filled every town and city with it, had planted churches in every place, and ordained elders over them, to whom the care and charge of them were committed; that there were no more places for him to preach in, but either where he himself had been already, or some other of the apostles; not but that he could have stayed with usefulness to these new formed churches, for the edifying and confirming of them, for the furtherance of the joy of faith in them, and for the defence of the Gospel and its ordinances among them; but his proper work as an apostle being to preach the Gospel to all nations, and where Christ was not named, and to plant churches; and there being no more room in these climates, or regions, for such service, he begins to think of some other places, particularly Spain, where as yet very probably the Gospel was not preached: however, he found himself at leisure to visit other places, and hereby gives the church at Rome some hopes of seeing him from this consideration, as well as from what follows:
and having a great desire these many years to come unto you; he had not only a desire, but a very vehement desire to come to them; he longed to see them, as he elsewhere says; so that since now he had leisure, they might hope it would not be long ere they did see him; especially as the thing had been upon his mind and thoughts for many years past; which shows that the Gospel had been preached very early at Rome, that many had been converted by it, and a church had been formed there some years ago, and was known to the apostle; on which account, having heard much of their faith and obedience, he had a longing desire of a great while to see them.

But now having no more place--"no longer having place"--that is, unbroken ground, where Christ has not been preached.
and having a great desire--"a longing"
these many years to come unto you--(as before, see on Romans 1:9-11).

Having no longer place in these parts - Where Christ has now been preached in every city.