And the four beasts said, Amen - The voice of universal praise came to them from abroad, and they accorded with it, and ascribed honor to God.
And the four and twenty elders fell down, - The living creatures and the elders began the work of praise Revelation 5:8, and it was proper that it should conclude with them; that is, they give the last and final response (Prof. Stuart). The whole universe, therefore, is sublimely represented as in a state of profound adoration, waiting for the developments to follow on the opening of the mysterious volume. All feel an interest in it; all feel that the secret is with God; all feel that there is but One who can open this volume; and all gather around, in the most reverential posture, awaiting the disclosure of the great mystery.
The truths taught in this chapter are the following:
(1) The knowledge of the future is with God, Revelation 5:1. It is as in a book held in his hand, fully written over, yet sealed with seven seals.
(2) it is impossible for man or angel to penetrate the future, Revelation 5:2-3. It seems to be a law of created being, that the ability to penetrate the future is placed beyond the reach of any of the faculties by which a creature is endowed. Of the past we have a record, and we can remember it; but no created being seems to have been formed with a power in reference to the future corresponding with that in reference to the past - with no faculty of foresight corresponding to memory.
(3) it is natural that the mind should be deeply affected by the fact that we cannot penetrate the future, Revelation 5:4. John wept in view of this; and how often is the mind borne down with heaviness in view of that fact! What things there are, there must be, in that future of interest to us! What changes there may be for us to experience; what trials to pass through; what happiness to enjoy; what scenes of glory to witness! What progress may we make in knowledge; what new friendships may we form; what new displays of the divine perfections may we witness! All our great interests are in the future - in what is to us now unknown. There is to be all the happiness which we are to enjoy, all the pain that we are to suffer; all that we hope, all that we fear. All the friends that we are to have are to be there; all the sorrows that we are to experience are to be there. Yet an impenetrable veil is set up to hide all that from our view. We cannot remove it; we cannot penetrate it. There it stands to mock all our efforts, and in all our attempts to look into the future we soon come to the barrier, and are repelled and driven back. Who has not felt his heart sad that he cannot look into what is to come?
(4) the power of laying open the future to mortals has been entrusted to the Redeemer, Revelation 5:5-7. It is a part of the work which was committed to him to make known to people as much as it was proper to be known. Hence, he is at once a prophet, and is the inspirer of the prophets. Hence, he came to teach people what is to be in the future pertaining to them, and hence he has caused to be recorded by the sacred writers all that is to be known of what is to come until it is slowly unfolded as events develop themselves. The Saviour alone takes the mysterious book and opens the seals; he only unrolls the volume and discloses to man what is to come.
(5) the fact that he does this is the foundation of joy and gratitude for the church, Revelation 5:8-10. It is impossible that the church should contemplate what the Saviour has revealed of the future without gratitude and joy; and how often, in times of persecution and trouble, has the church joyfully turned to the developments made by the Saviour of what is to be when the gospel shall spread over the world, and when truth and righteousness shall be triumphant.
(6) this fact is of interest to the angelic beings, and for them also it lays the foundation of praise, Revelation 5:11-12. This may arise from these causes:
(a) from the interest which they take in the church, and the happiness which they have from anything that increases its numbers or augments its joy:
(b) from the fact that in the disclosures of the future made by the Redeemer, there may be much that is new and of interest to them (compare notes on 1-Peter 1:12); and,
(c) from the fact that they cannot but rejoice in the revelations which are made of the final triumphs of truth in the universe.
(7) the universe at large has an interest in these disclosures, and the fact that they are to be made by the Redeemer lays the foundation for universal joy, Revelation 5:13-14. These events pertain to all worlds, and it is proper that all the inhabitants of the universe should join in the expressions of adoration and thanksgiving. The universe is one; and what affects one portion of it really pertains to every part of it. Angels and human beings have one and the same God and Father, and may unite in the same expressions of praise.

The four beasts said, Amen - Acknowledged that what was attributed to Christ was his due.
The four and twenty elders - The word εικοσιτεσσαρες, twenty-four, is wanting in the most eminent MSS. and versions.
Fell down and worshipped - Επεσαν και προσεκυνησαν· Fell down on their knees, and then prostrated themselves before the throne. This is the eastern method of adoration: first, the person worshiping fell down on his knees; and then, bowing down touched the earth with his forehead. This latter act was prostration.
Him that liveth for ever - This clause is wanting in ABC, thirty-seven others, Syriac, Arabic, Coptic, Ethiopic, some copies of the Slavonic, Itala, and Vulgate; and in Andreas, and Arethas, ancient commentators on this book. It is also wanting in some editions, and is undoubtedly spurious. Griesbach has left this and the above twenty-four out of the text.
Now follow the least intelligible parts of this mysterious book, on which so much has been written, and so much in vain. It is natural for man to desire to be wise; and the more difficult the subject the more it is studied, and the hope of finding out something by which the world and the Church might be profited, has caused the most eminently learned men to employ their talents and consume their time on these abstruse prophecies. But of what use has all this learned and well-meant labor been to mankind? Can hypothesis explain prophecy, and conjecture find a basis on which faith can rest? And what have we better in all attempts hitherto made to explain the mysteries of this book?

(16) And the four beasts said, Amen. And the four [and] twenty elders fell down and worshipped him that liveth for ever and ever.
(16) A confirmation of the praise given before, from the consent of the nobles, expressed in word and signs, as once or twice before this.

And the four beasts said, Amen,.... Giving their assent to what the angels and every creature said, and expressing their desires and wishes that so it might be, and also their faith, that so it was, and would be:
and the four and twenty elders fell down and worshipped him that liveth for ever and ever; either God the Father, who sat upon the throne, and is so described, Revelation 4:9; or else the Lamb who had been slain, and was now alive, and lives for evermore; or both of them, for the Alexandrian copy, the Complutensian edition, and the Syriac and Arabic versions, omit the words "him that liveth for ever and ever"; and leave it to be understood of either of them, or both; and the Ethiopic version reads, "and the elders worshipped him"; as the four living creatures and four and twenty elders led the chorus, and begun the song, so they close it, as being the persons more immediately concerned in the death and sufferings of the Lamb, and redemption by him, and in the sealed book, and in the things contained in it; the seals of which are next opened, and an account is given of them in some following chapters.

said--So A, Vulgate, and Syriac read. But B and Coptic read, "(I heard) saying."
Amen--So A reads. But B reads, "the (accustomed) Amen." As in Revelation 4:11, the four and twenty elders asserted God's worthiness to receive the glory, as having created all things, so here the four living creatures ratify by their "Amen" the whole creation's ascription of the glory to Him.
four and twenty--omitted in the oldest manuscripts: Vulgate supports it.
him that liveth for ever and ever--omitted in all the manuscripts: inserted by commentators from Revelation 4:9. But there, where the thanksgiving is expressed, the words are appropriate; but here less so, as their worship is that of silent prostration. "Worshipped" (namely, God and the Lamb). So in Revelation 11:1, "worship" is used absolutely.