And there shall in no wise - On no account; by no means. This strong language denotes the absolute exclusion of all that is specified in the verse.
Anything that defileth - Literally, anything "common." See the notes on Acts 10:14. It means here that nothing will be found in that blessed abode which is unholy or sinful. It will be a pure world, 2-Peter 3:13.
Neither whatsoever worketh abomination, or maketh a lie - See the notes on Revelation 21:8.
But they which are written in the Lamb's book of life - Whose names are there recorded. See the notes on Revelation 3:5. Compare the notes on Revelation 21:8.

There shall in nowise enter into it any thing that defileth - See Isaiah 35:8; Isaiah 52:1. Neither an impure person - he who turns the grace of God into lasciviousness, nor a liar - he that holds and propagates false doctrines.
But they which are written - The acknowledged persevering members of the true Church of Christ shall enter into heaven, and only those who are saved from their sins shall have a place in the Church militant.
All Christians are bound by their baptism to renounce the devil and all his works, the pomps and vanities of this wicked world, and all the sinful lusts of the flesh; to keep God's holy word and commandments; and to walk in the same all the days of their life. This is the generation of them that seek thy face, O God of Jacob! Reader, art thou of this number? Or art thou expecting an eternal glory while living in sin? If so, thou wilt be fearfully disappointed. Presuming on the mercy of God is as ruinous as despairing of his grace. Where God gives power both to will and to do, the individual should work out his salvation with fear and trembling.

And there shall in no wise enter into it anything that defileth,.... As evil thoughts, words, and actions do; and therefore he that enters into this city must be free from all these: or "that is defiled", as the Vulgate Latin and Syriac versions read; or "that is unclean", as the Arabic and Ethiopic versions; alluding to the tabernacle and temple, into which no unclean person might come; see Isaiah 52:1. No profane sinner, whose mind and conscience are defiled, and whose conversation is defiling, may enter here; nor any self-righteous person, whose righteousness is as filthy rags, and he himself is as an unclean thing, shall be admitted here; only such who are washed in the blood of Christ, and have on his righteousness, and so are without spot or wrinkle; which shows the pure and perfect state of this church and therefore cannot design any state of the church previous to the coming of Christ and the first resurrection:
neither whatsoever worketh abomination; commits sin, which is abominable in the sight of God, lives and dies in a course of wickedness; or particularly is guilty of idolatry, either makes idols, or serves them, or both, which are an abomination to the Lord; see
or maketh a lie; any lie in general; who is a common liar, loves and invents a lie, and speaks one; delivers that which is false with an intention to deceive; or in particular, who embraces and propagates antichristian lies, doctrinal ones, lies spoken in hypocrisy; such shall be damned; see 1-Timothy 4:1 but they which are written in the Lamb's book of life; who are predestinated to eternal life; and though they are naturally, and in themselves defiled and sinful creatures, yet they are justified by the righteousness of Christ, and sanctified by his Spirit, and so are made meet and fit to enter this city; See Gill on Revelation 13:8. It is by the Jews observed (d), that
"the Jerusalem of the world to come is not as the Jerusalem of this world; the Jerusalem of this world, whoever would go up to it (or enter into it) might; but that of the world to come, , "none may go up to it (or enter into it) but those who are prepared", or appointed for it.''
(d) T. Bab. Bava Bathra, fol. 75. 2.

anything that defileth--Greek, "koinoun." A and B read [koinon,] "anything unclean."
in the Lamb's book of life--(See on Revelation 20:12; Revelation 20:15). As all the filth of the old Jerusalem was carried outside the walls and burnt there, so nothing defiled shall enter the heavenly city, but be burnt outside (compare Revelation 22:15). It is striking that the apostle of love, who shows us the glories of the heavenly city, is he also who speaks most plainly of the terrors of hell. On Revelation 21:26-27, ALFORD writes a Note, rash in speculation, about the heathen nations, above what is written, and not at all required by the sacred text: compare Note, see on Revelation 21:26.

Common - That is. unholy. But those who are written in the Lamb's book of life - True, holy, persevering believers. This blessedness is enjoyed by those only; and, as such, they are registered among them who are to inherit eternal life.