Saying, God hath forsaken him - That is, God has given him over; he no longer protects him; he regards him as a wicked man, and we shall therefore, not only be "safe" in our attempts upon his life, but we shall be "justified" in those attempts.
Persecute and take him - It can be done safely now; it can be done with propriety.
For there is none to deliver him - He has no one now to whom to look; no one on whom he can rely. Abandoned by God and by man, he will be an easy prey. Compare the notes at Psalm 41:7-8.

God hath forsaken him - "God, who has been his special help all through life, and who has guarded him so that no hand could be raised successfully against him, has now cast him off; therefore we shall easily prevail against him. His present adversity shows that God is no longer his friend." Thus men judge. "Secular prosperity is a proof of God's favor: adversity is a proof of his displeasure." But this is not God's way, except in especial judgments, etc. He never manifests his pleasure or displeasure by secular good or ill.

Saying, (h) God hath forsaken him: persecute and take him; for [there is] none to deliver [him].
(h) Thus the wicked both blaspheme God and triumph against his saints, as though he had forsaken them if he permits them to fall into their hands.

Saying, God hath forsaken him,.... Good men may seem to others to be forsaken of God; and they themselves may sometimes think they are; and they may be forsaken for a small moment, when God withdraws his gracious presence, or does not afford immediate help; but never finally and totally. This David's enemies concluded, from the distressed condition he was in, being obliged to leave his family and court, and flee from his son, and wander up and down with a small retinue; and this they said to one another, to encourage themselves to lay violent hands upon him, which they thought they might do with ease and impunity; wherefore it follows,
persecute and take him; pursue after him eagerly and diligently; lose no time; and, when come up to him, seize upon him, without any fear of God or man;
for there is none to deliver him; out of our hands. God will not, for he has forsaken him; and men cannot, for he has not an army sufficient to defend him or recover him.