Cast me not away from thy presence - That is, Do not reject me, or cast me off entirely; do not abandon me; do not leave me in my sin and sorrow. The language is derived from the idea that true happiness is to be found in the "presence" of God, and that to be exiled from him is misery. Compare Psalm 16:11, note; Psalm 31:20, note. See also Psalm 140:13.
And take not thy holy Spirit from me - It is not certain that David understood by the phrase "thy Holy Spirit" precisely what is now denoted by it as referring to the third person of the Trinity. The language, as used by him, would denote some influence coming from God producing holiness, "as if" God breathed his own spirit, or his own self, into the soul. The language, however, is appropriate to be used in the higher and more definite sense in which it is now employed, as denoting that sacred Spirit - the Holy Spirit - by whom the heart is renewed, and by whom comfort is imparted to the soul. It is not necessary to suppose that the inspired writers of the Old Testament had a full and complete comprehension of the meaning of the words which they employed, or that they appreciated all that their words might properly convey, or the fullness of signification in which they might be properly used in the times of the Gospel. Compare the notes at 1-Peter 1:10-12. The language used here by David - "take not" - implies that he had been formerly in possession of that which he now sought. There was still in his heart that which might be regarded as the work of the Spirit of God; and he earnestly prayed that that might not be wholly taken away on account of his sin, or that he might not be entirely abandoned to despair.

Cast me not away from thy presence - Banish me not from thy house and ordinances.
Take not thy Holy Spirit from me - I know I have sufficiently grieved it to justify its departure for ever, in consequence of which I should be consigned to the blackness of darkness, - either to utter despair, or to a hard heart and seared conscience; and so work iniquity with greediness, till I fell into the pit of perdition. While the Spirit stays, painfully convincing of sin, righteousness, and judgment, there is hope of salvation; when it departs, then the hope of redemption is gone. But while there his any godly sorrow, any feeling of regret for having sinned against God, any desire to seek mercy, then the case is not hopeless; for these things prove that the light of the Spirit is not withdrawn.

Cast me not away from thy presence,.... As abominable; as a vessel in which he had no pleasure; with indignation and wrath; as one that is angry with another, cannot bear him in his sight, but bids him be gone from him. Nothing is more desirable to a child of God than the presence of God; and nothing gives him more sensible pain than his absence; and even to be deprived of or denied the means of enjoying his presence the word and ordinances, makes them very uneasy: to be utterly, and for ever deprived of it, is the case of the damned in hell, and is the punishment of loss they sustain; and, on the other hand, the happiness of the saints in heaven is to enjoy it without interruption. The people of God are never cast away from his favour, or out of his heart's love; but they may for a while be without his gracious presence, or not see his face, nor have the light of his countenance, nor sensible communion with him, which is here deprecated. David might call to mind the case of Cain, Genesis 4:14; or rather the more recent one of Saul, whom the Lord rejected, and from whom he departed upon his sinning, and which he might fear would be his case, 1-Samuel 28:15;
and take not thy Holy Spirit from me; or "the Spirit of thine holiness"; the third Person in the Trinity; so called, not because this epithet of "holy" is peculiar to him; for it is used also of the Father, and of the Son, John 17:11; but because he is equally holy with them, and is the author of holiness in his people, which is therefore called the sanctification of the Spirit, 1-Peter 1:2; and without whom David knew that purity and holiness of heart and spirit he had desired could not be renewed and increased in him; and therefore deprecates the taking of him away; which shows that he was not as yet removed from him, not with standing he had fallen into great sins; and his sense of sin, and confession of it, and his fervent application for pardoning grace, and purity of heart, abundantly prove it. The Spirit of God is a gift of his, which is without repentance, and where he once is as a spirit of regeneration and sanctification, he ever abides: his external gifts may be taken away; but internal grace is an incorruptible seed, and always continues. By sin the Spirit of God may be grieved, so as to withdraw his gracious influences, and his powerful operations may not be felt; and this is what is here deprecated. The Targum interprets this of the spirit of prophecy which David had, by which he composed psalms and songs prophetic of Christ, and of Gospel times, and which was not taken away from him; see 2-Samuel 23:1.