He hath regarded the prayer of the solitary It is worthy of notice, that the deliverance of the chosen tribes is ascribed to the prayers of the faithful. God's mercy was indeed the sole cause which led him to deliver his Church, according as he had graciously promised this blessing to her; but to stir up true believers to greater earnestness in prayer, he promises that what he has purposed to do of his own good pleasure, he will grant in answer to their requests. Nor is there any inconsistency between these two truths, that God preserves the Church in the exercise of his free mercy, and that he preserves her in answer to the prayers of his people; for as their prayers are connected with the free promises, the effect of the former depends entirely upon the latter. When it is said, that the prayers of the solitary were heard, it is not to be understood of one man only, (for in the clause immediately following, the plural number is used;) but all the Jews, so long as they remained ejected from their own country, and lived as exiles in a strange land, are called solitary, because, although the countries of Assyria and Chaldea were remarkably fertile and delightful, yet these wretched captives, as I have previously observed, wandered there as in a wilderness. And as at that time this solitary people obtained favor by sighing, so now when the faithful are scattered, and are without their regular assemblies, the Lord will hear their groanings in this desolate dispersion, provided they all with one consent, and with unfeigned faith, earnestly breathe after the restoration of the Church.

He will regard the prayer - literally, "He looks upon," or "he 'turns himself' to their prayer." He does not any longer seem to turn away from them and disregard them. He shows by thus building up Zion that he does regard prayer; that he hears the supplications of his people. There is no higher proof that prayer is heard than that which is often furnished in a revival of pure religion. All such revivals, like that on the day of Pentecost (Acts 2:1 ff), are usually preceded, as that was Acts 1:13-14, by special prayer; in those revivals there are often most manifest and clear answers to prayer for the conversion of individuals; to prayer for a blessing on a preached gospel; to prayer for particular relatives and friends.
Of the destitute - literally, "of the poor." The word - ערער ‛ar‛âr - occurs only here and in Jeremiah 17:6, where it is rendered "heath:" "He shall be like the 'heath' in the desert." The word, according to its etymology, means "naked;" then, poor, stripped of everything, impoverished, wholly destitute. It would thus be eminently applicable to the poor exiles in Babylon; it is as applicable to sinners pleading with God, and to the people of God themselves, destitute of everything like self-righteousness, and feeling that they have nothing in themselves, but that they are wholly dependent on the mercy of God. Compare Revelation 3:17.
And not despise their prayer - Not treat it with contempt; not pass it by unheard. This is stated as one of the reasons why the nations would be struck with awe - that God, the infinite God, would hear the prayers of those who were so poor, so powerless, so friendless. There is, in fact, nothing more suited to excite wonder than that God does hear the prayer of poor, lost, sinful man.

The prayer of the destitute - הערער haarar of him who is laid in utter ruin, who is entirely wasted.

He will regard the prayer of the destitute,.... Of the destitute of human help and support, protection and defence; as the church in the wilderness; of the "poor", as the Syriac and Arabic versions, both in spirit and in purse; of the "humble", as the Septuagint and Vulgate Latin: the word (c) signifies a low shrub or plant; it is rendered, the heath in the wilderness, Jeremiah 17:6 and designs the saints in their low and afflicted state, during the reign of antichrist, and while the witnesses prophesy in sackcloth; these are the elect that pray day and night, and give the Lord no rest till he establish and make Jerusalem a praise in the earth; and the prayers of these are regarded and looked to by the Lord; his eyes are upon and his ears are open to these praying ones; and all the glorious things which shall be done for the church of God will be in consequence of their prayers:
and not despise their prayer; not reject it with contempt and abhorrence; more is intended than is expressed: the meaning is, that he will receive it with pleasure, and return an answer to it; the prayer of these poor destitute ones is delightful to him, Proverbs 15:8.
(c) "eorum, qui sunt veluti myricae", Pagninus, Vatablus, Cocceius.