Odious woman - One in whom there is nothing loveable. Marriage, which to most women is the state in which they find scope for their highest qualities, becomes to her only a sphere in which to make herself and others miserable.

For an odious [woman] when she is married; and an handmaid that is (m) heir to her mistress.
(m) Who is married to her master after the death of her mistress.

For an odious woman, when she is married,.... Odious for her person, her ugliness, and the deformity of her body; or rather for the ill qualities of her mind, which, while single, she endeavours to conceal, but, being married, hides them no longer; but becomes imperious, proud, scornful, and malicious, and behaves in an ill natured way to her husband and all about her, to such a degree, that there is no bearing the place where she is;
and an handmaid, that is heir to her mistress; that has got so much into her affections that she leaves all she has to her when she dies, which makes her insufferably proud and vain; or she marries her master after the death of her mistress, and so coming into her place enjoys all she had, but only her wisdom and humility; which being wanting, she behaves in such a manner as to make the whole family uneasy. This might be exemplified in the case of Hagar, the bondmaid of Sarah, a type of those that are under the law of works, and seek the inheritance by it; and who trust in themselves that they are righteous, and despise others, Genesis 16:4.

heir . . . mistress--that is, takes her place as a wife (Genesis 16:4).

An odious - Proud, and perverse. Married - For then she displays all those ill humours, which before, she concealed. Is heir - Which great and sudden change transports her beside herself, and makes her insufferably proud and scornful.