The words describe more than the fatal persistency of the sinful habit when once formed. A resurrection from that world of the dead to "the paths of life" is all but impossible.

None that go unto her return again - There are very few instances of prostitutes ever returning to the paths of sobriety and truth; perhaps not one of such as become prostitutes through a natural propensity to debauchery. Among those who have been deceived, debauched, and abandoned, many have been reclaimed; and to such alone penitentiaries may be useful; to the others they may only be incentives to farther sinning. Rakes and debauchees are sometimes converted: but most of them never lay hold on the path of life; they have had their health destroyed, and never recover it. The original, חיים chaiyim, means lives; not only the health of the body is destroyed, but the soul is ruined. Thus the unhappy man may be said to be doubly slain.

None that go unto her return again,.... That is, those that commit whoredom with her return not again by repentance, and to a sober and chaste way of living, at least but very few; hence some of the ancients thought adultery was the unpardonable sin; but it is certain that some have been recovered by the power of divine grace, and have been brought to repentance for their impure manner of life, and have truly believed in Christ, and lived sober and godly lives afterwards; but, as the Targum adds, they do not return "in peace", but with great distress of mind, remorse of conscience, and bitterness of soul; and these instances are rare; generally speaking, such as are ensnared by an adulterous woman, whose heart is snares and nets, and whose hands are as bands, are held so fast by her that they seldom get out again, though some few may escape, Ecclesiastes 7:26. The words may be rendered, "all that go into her (z) shall not return again"; no, very few of them. And it is a very rare thing, when men are fallen into idolatry, superstition, will worship, and heresy, that they are recovered out of this snare of the devil; there is a peradventure they may, but it is not often that they be loosed from it, 2-Timothy 2:25;
neither take they hold of the paths of life; Christ, and the ways of Christ, which lead to eternal life; few there be that find these paths and walk in them, Matthew 7:14; and especially such as are drawn aside by an impure woman, they are held so fast by her alluring charms, and so bewildered by her art of deceiving, that they are like persons that are led out of their way, and cannot find it again.
(z) "omnes ingredientes eam", Pagninus, Montanus.

that is, such as remain impenitent (compare Ecclesiastes 7:26).
paths of life-- (Psalm 16:11), opposed to paths unto the dead.