He began to be affected with grief. We have seen that our Lord formerly contended with the fear of death; but as he now fights face to face with temptation, such an attack is called the beginning of grief and sorrow. Hence we infer that the true test of virtue is only to be found when the contest begins; for then the weakness of the flesh, which was formerly concealed, shows itself, and the secret feelings are abundantly displayed. Thus, though God had already tried his Son by certain preparatory exercises, he now wounds him more sharply by a nearer prospect of death, and strikes his mind with a terror to which he had not been accustomed. But as it appears to be inconsistent with the divine glory of Christ, that he was seized with trembling and sadness, many commentators have labored with toil and anxiety to find some way of evading the difficulty. But their labor has been ill-judged and of no use; for if we are ashamed that Christ should experience fear and sorrow, our redemption will perish and be lost. Ambrose justly says: "I not only do not think that there is any need of excuse, but there is no instance in which I admire more his kindness and his majesty; for he would not have done so much for me, if he had not taken upon him my feelings. He grieved for me, who had no cause of grief for himself; and, laying aside the delights of the eternal Godhead, he experiences the affliction of my weakness. I boldly call it sorrow, because I preach the cross. For he took upon him not the appearance, but the reality, of incarnation. It was therefore necessary that he should experience grief, that he might overcome sorrow, and not shut it out; for the praise of fortitude is not bestowed on those who are rather stupefied than pained by wounds." Thus far Ambrose. Certainly those who imagine that the Son of God was exempt from human passions do not truly and sincerely acknowledge him to be a man. And when it is even said that the divine power of Christ rested and was concealed for a time, that by his sufferings he might discharge all that belonged to the Redeemer, this was so far from being absurd, that in no other way could the mystery of our salvation have been accomplished. For Cyril has properly said: "That the suffering of Christ on the cross was not in every respect voluntary, but that it was voluntary on account of the will of the Father, and on account of our salvation, you may easily learn from his prayer, Father, if it be possible, let this cup pass from me. For the same reason that the Word of God is God, (John 1:1,) and is naturally life itself, (John 11:25,) nobody doubts that he had no dread of death; but, having been made flesh, (John 1:14,) he allows the flesh to feel what belongs to it, and, therefore, being truly a man, he trembles at death, when it is now at the door, and says, Father, if it be possible, let this cup pass from me; but since it cannot be otherwise, let it be not as I will, but as thou wilt. You see how human nature, even in Christ himself, has the sufferings and fears which belong to it, but that the Word, who is united to it, raises it to a fortitude which is worthy of God." He at length concludes: "You perceive that it was not for the sake of the flesh that the death of Christ was voluntary, but that it was voluntary, because, on account of it, according to the will of the Father, salvation and life were bestowed on men." Such are the views of Cyril. Still the weakness which Christ took upon himself must be distinguished from ours, for there is a great difference. In us there is no affection unaccompanied by sin, because they all exceed due bounds and proper restraint; but when Christ was distressed by grief and fear, he did not rise against God, but continued to be regulated by the true rule of moderation. We need not wonder that, since he was innocent, and pure from every stain, the affections which flowed from him were pure and stainless; but that nothing proceeds from the corrupt nature of men which is not impure and filthy. Let us, therefore, attend to this distinction, that Christ, amidst fear and sadness, was weak without any taint of sin; but that all our affections are sinful, because they rise to an extravagant height. The kind of feelings, by which Christ was tempted, is also worthy of notice. Matthew says that he was affected by grief and sorrow (or anxiety;)Luke says that he was seized with anguish; and Mark adds that he trembled. And whence came his sorrow and anguish, and fear, but because he felt that death had something in it more sad and more dreadful than the separation of the soul and body? And certainly he underwent death, not merely that he might depart from earth to heaven, but rather that, by taking upon himself the curse to which we were liable, he might deliver us from it. He had no horror at death, therefore, simply as a passage out of the world, but because he had before his eyes the dreadful tribunal of God, and the Judge himself armed with inconceivable vengeance; and because our sins, the load of which was laid upon him, pressed him down with their enormous weight. There is no reason to wonder, therefore, if the dreadful abyss of destruction tormented him grievously with fear and anguish.

And he took with him Peter and the two sons of Zebedee - That is, James and John, Matthew 10:2. On two other occasions he had favored these disciples in a particular manner, suffering them to go with him to witness his power and glory, namely, at the healing of the ruler's daughter Luke 8:51, and at his transfiguration on the mount, Matthew 17:1.
Sorrowful - Affected with grief.
Very heavy - The word in the original is much stronger than the one translated "sorrowful." It means, to be pressed down or overwhelmed with great anguish. This was produced, doubtless, by a foresight of his great sufferings on the cross in making an atonement for the sins of people.

And he took with him Peter and the two sons of Zebedee - That is, James and John; the same persons who had beheld his transfiguration on the mount - that they might contemplate this agony in the light of that glory which they had there seen; and so be kept from being stumbled by a view of his present humiliation.
Began to be sorrowful - Λυπεισθαι, from λυω, to dissolve - exquisite sorrow, such as dissolves the natural vigor, and threatens to separate soul and body.
And very heavy - Overwhelmed with anguish - αδημονειν. This word is used by the Greeks to denote the most extreme anguish which the soul can feel - excruciating anxiety and torture of spirit.

And he took with him Peter and the two sons of Zebedee, and began to be sorrowful and (r) very heavy.
(r) The word which he uses signifies great sorrow, and tremendous and deadly grief: this thing, as it indicates man's true nature, which shuns death as a thing that entered in against nature, shows that though Christ was void of sin, yet he sustained this horrible punishment, because he felt the wrath of God kindled against us for sins, which he revenged and punished in his person.

And he took with him Peter, and the two sons of Zebedee,.... James and John, who perhaps were the strongest, and best able to bear the shocking sight, and were his favourite disciples; who were admitted to be with him at other times, when the rest were not; as at the raising of Jairus's daughter, Mark 5:37, and moreover, these were at his transfiguration on the mount, Matthew 17:1, which was a representation and presage of his glory; and so were very proper persons to be witnesses of his sorrows and agonies, which were the way to it; and three of them were taken by him for this purpose, being a sufficient number to bear testimony, since by the mouth of two or three witnesses everything is established:
and began to be sorrowful; his soul was troubled on the same account six days before, John 12:27, but was now sorrowful. He was a man of sorrows all his days, and acquainted with griefs, being reproached and persecuted by men: but now a new scene of sorrows opened; before he was afflicted by men, but now he is bruised, and put to grief by his Father: his sorrows now began, for they did not end here, but on the cross; not that this was but a bare beginning of his sorrows, or that these were but light in comparison of future ones; for they were very heavy, and indeed seem to be the heaviest of all, as appears from his own account of them; his vehement cry to his Father; his bloody sweat and agony; and the assistance he stood in need of from an angel; and the comfort and strength he received from him in his human nature: all which, put together, the like is not to be observed in any part of his sufferings:
and to be very heavy; with the weight of the sins of his people, and the sense of divine wrath, with which he was so pressed and overwhelmed, that his spirits were almost quite gone; he was just ready to swoon away, sink and die; his heart failed him, and became like wax melted in the midst of his bowels, before the wrath of God, which was as a consuming fire: all which shows the truth, though weakness of his human nature, and the greatness of his sufferings in it. The human nature was still in union with the divine person of the Son of God, and was sustained by him, but left to its natural weakness, without sin, that it might suffer to the utmost, and as much as possible for the sins of God's elect.

And he took with him Peter and the two sons of Zebedee. The eight were left at the entrance of the garden, while the three, who had always been a kind of inner circle, who had been witnesses of his transfiguration, and of one of his greatest miracles (Mark 5:37), were taken within.
Began to be sorrowful and very heavy. The shadow of the cross had fallen upon him. It was not fear of the agony, or fear of death, for he bore all, when the moment came, so sublimely that a heathen officer exclaimed, "Surely he must be the son of a god." I doubt whether it is possible for a mortal to comprehend the mystery of his suffering, but I think the key is found in the declaration, "He was made sin for us."

And taking with him Peter and the two sons of Zebedee - To be witnesses of all; he began to be sorrowful and in deep anguish - Probably from feeling the arrows of the Almighty stick fast in his soul, while God laid on him the iniquities of us all. Who can tell what painful and dreadful sensations were then impressed on him by the immediate hand of God? The former word in the original properly signifies, to be penetrated with the most exquisite sorrow; the latter to be quite depressed, and almost overwhelmed with the load.