But they neglected, and went their own ways, one to his farm, and another to his merchandise.

But they made light of it, and went, one to his own land, and another to his commerce.

and they, having disregarded it, went away, the one to his own field, and the other to his merchandise;

"They however gave no heed, but went, one to his home in the country, another to his business;

But they gave no attention, and went about their business, one to his farm, another to his trade:

But they ignored this and they went away: one to his country estate, and another to his business.

They, however, took no notice, but went off, one to their farm, another to their business;

But they made light of it - Treated it with contempt, as a thing of no consequence - an exact representation of the conduct of sinners in regard to the gospel.
One to his farm - So people are engaged so much in their worldly employment that they pretend they have no time to attend to religion. The world is, in their view, of more value than God.
Merchandise - Traffic; trading.

But they made light of it,.... The invitation. They neglected the ministry of the Gospel; they did not care for it, nor showed any regard to it: and this is the ease, when either it is not attended on, though there is an opportunity, yet having no heart to embrace it, and no value for it, neglect attendance on it; and which often arises from loving of the world too much: or when it is attended on, but in a very negligent and careless manner; when men pull away the shoulder, or stop their ears; when they do not mind what they hear, let it slip and forget it; when they are unconcerned for it, and their thoughts are employed about other things: or when the Gospel and the ordinances of it are looked upon as things of no importance; not knowing the real worth and value of them; seeing no wisdom in them, having never tasted the sweetness, or felt the power of them, or seen the need of the things revealed by them: as also when there is an aversion to the Gospel, a loathing of it, as a novel, upstart doctrine, received but by a few, and these the meanest and most illiterate; as contrary to reason, and tending to licentiousness; and especially, when it is contradicted and blasphemed, as it was by the Jews, and its ministers despised: some men make light of it, because of the loss of time from worldly employments; because of the charge attending it; because it teaches them to deny ungodliness and worldly lusts; and because they prefer their bodies to their souls, and things temporal, to things eternal. The aggravations of their sin, in slighting and neglecting the Gospel and Gospel ordinances, are, that this is a grand entertainment, a very expensive provision, as well as a very plentiful one; that it was a wedding dinner, a feast of love, they were invited to; that it was prepared by so great a person as a king, and who is the King of kings, and the only potentate; who provided this dinner of his own sovereign good will and pleasure, in the everlasting council and covenant of grace and peace: for the things of which it consists, there was a scheme so early contrived to bring them about; and that this was made on the account of the marriage of his Son, the Messiah, who had been so often spoken of by the prophets of the Old Testament, these men professed a value for; one so long expected by their forefathers, and is the messenger of the covenant, whose coming they themselves desired and sought for; and that they should be invited to it again and again, and one set of servants sent after another, and the most striking and moving arguments made use of; and yet they slighted and made light of all this, and were careless and unconcerned; to which may be added, that the things they were invited to, were such as concerned their immortal souls, and the spiritual and eternal welfare of them; in short, it was no other than the great salvation, wrought out by the great God, and our Saviour, for great sinners, at the expense of his blood and life, which they neglected; See Gill on Hebrews 2:3.
And went their ways, one to his farm, another to his merchandise: they all turned their backs on the Gospel, and the ministration of it, and pursued their own worldly inclinations, ways, and methods of life: those that were brought up in a rural way, lived a country life, and were concerned in meaner employments, went everyone to their "village", as the Vulgate Latin, and Munster's Hebrew Gospel read it, and to their farms, there to manage their cattle, and till their ground; and others, that lived in larger towns and cities, and were concerned in greater business of life, betook themselves to trade at home, or traffic abroad; placing their happiness in the affluence of this life, which they preferred to the word and ordinances of Christ. Such a division of worldly employment is made by the Jews (k);
"the way of that host is like to a king, who makes a grand entertainment, and says to the children of his palace, all the rest of the days ye shall be everyone in his house; this shall do his business, , "and this shall go about his merchandise", , "and this shall go to his field", except on my day.''
(k) Zohar in Leviticus. fol. 40. 2.

But they made light of it, and went their ways, one to his farm, another to his merchandise:

But they made light of it. There were two classes that refused to heed the invitation. This is the first class, those who are indifferent.

One to his farm, another to his merchandise - One must mind what he has; another, gain what he wants. How many perish by misusing lawful things!