For what doth it profit a man? The word soul is here used in the strictest sense. Christ reminds them that the soul of man was not created merely to enjoy the world for a few days, but to obtain at length its immortality in heaven. What carelessness and what brutal stupidity is this, that men are so strongly attached to the world, and so much occupied with its affairs, as not to consider why they were born, and that God gave them an immortal soul, in order that, when the course of the earthly life was finished, they might live eternally in heaven! And, indeed, it is universally acknowledged, that the soul is of higher value than all the riches and enjoyments of the world; but yet men are so blinded by carnal views, that they knowingly and willfully abandon their souls to destruction. That the world may not fascinate us by its allurements, let us remember the surpassing worth of our soul; for if this be seriously considered, it will easily dispel the vain imaginations of earthly happiness.

For what is a man profited - To gain the whole world means to possess it as our own - all its riches, its honors, and its pleasures.
"To lose his own soul" means to be cast away, to be shut out from heaven, to be sent to hell. Two things are implied by Christ in these questions:
1. That they who are striving to gain the world, and are unwilling to give it up for the sake of religion, will lose their souls; and,
2. That if the soul is lost, nothing can be given in exchange for it, or that it can never afterward be saved. There is no redemption in hell.

Lose his own soul - Or, lose his life, την ψυχην αυτου. On what authority many have translated the word ψυχη, in the 25th verse, life, and in this verse, soul, I know not, but am certain it means life in both places. If a man should gain the whole world, its riches, honors, and pleasures, and lose his life, what would all these profit him, seeing they can only be enjoyed during life? But if the words be applied to the soul, they show the difficulty - the necessity - and importance of salvation. The world, the devil, and a man's own heart are opposed to his salvation; therefore it is difficult. The soul was made for God, and can never be united to him, nor be happy, till saved from sin: therefore it is necessary. He who is saved from his sin, and united to God, possesses the utmost felicity that the human soul can enjoy, either in this or the coming world: therefore, this salvation is important. See also the note on Luke 9:25 (note).

For what is a man profited,.... Such persons, though they are only seeking their own profit, will find themselves most sadly mistaken; for of what advantage will it be to such a man,
if he shall gain the whole world; all that is precious and valuable in it; all the power, pleasures, and riches of it; if with Alexander, he had the government of the whole world, and with Solomon, all the delights of it; and was possessed with the wealth of Croesus, and Crassus,
and lose his own soul? If that should be consigned to everlasting torment and misery, be banished the divine presence, and continually feel the gnawings of the worm of conscience that never dies, and the fierceness of the fire of God's wrath, that shall never be quenched, he will have a miserable bargain of it.
Or what shall a man give in exchange for his soul? Or, "for the redemption" of it, as the Ethiopic version renders it: see Psalm 49:8. If he had the whole world to give, and would give it, it would not be a sufficient ransom for it; the redemption of an immortal soul requires a greater price than gold and silver, or any corruptible thing; nothing short of the blood and life of Christ, is a proper exchange, or ransom price for it. But in the other world there will be no redemption; the loss of a soul is irrecoverable: a soul once lost and damned, can never be retrieved. This passage is thought to be proverbial; what comes nearest to it, is the following (x).
"If a scholar dies, we never find an exchange for him; there are four things which are the ministry or service of the world, , if they are lost, they may be changed; and they are these, gold, silver, iron, and brass, Job 28:1 but if a scholar dies, , who will bring us his exchange? or an exchange for him: we lost R. Simon, "who will bring us his exchange?".''
(x) Midrash Kohelet, fol. 72. 3, 4. T. Hieros. Beracot, fol. 5. 3.

For what is a man profited, if he shall gain the whole world, and lose his own soul--or forfeit his own soul?
or what shall a man give in exchange for his soul?--Instead of these weighty words, which we find in Mark 8:36 also, it is thus expressed in Luke 9:25 : "If he gain the whole world, and lose himself, or be cast away," or better, "If he gain the whole world, and destroy or forfeit himself." How awful is the stake as here set forth! If a man makes the present world--in its various forms of riches, honors, pleasures, and such like--the object of supreme pursuit, be it that he gains the world; yet along with it he forfeits his own soul. Not that any ever did, or ever will gain the whole world--a very small portion of it, indeed, falls to the lot of the most successful of the world's votaries--but to make the extravagant concession, that by giving himself entirely up to it, a man gains the whole world; yet, setting over against this gain the forfeiture of his soul--necessarily following the surrender of his whole heart to the world--what is he profited? But, if not the whole world, yet possibly something else may be conceived as an equivalent for the soul. Well, what is it?--"Or what shall a man give in exchange for his soul?" Thus, in language the weightiest, because the simplest, does our Lord shut up His hearers, and all who shall read these words to the end of the world, to the priceless value to every man of his own soul. In Mark and Luke (Mark 8:38; Luke 9:26) the following words are added: "Whosoever therefore shall be ashamed of Me and of My words [shall be ashamed of belonging to Me, and ashamed of My Gospel] in this adulterous and sinful generation" (see on Matthew 12:39), "of him shall the Son of man be ashamed when He cometh in the glory of His Father, with the holy angels." He will render back to that man his own treatment, disowning him before the most august of all assemblies, and putting him to "shame and everlasting contempt" (Daniel 12:2). "O shame," exclaims BENGEL, "to be put to shame before God, Christ, and angels!" The sense of shame is founded on our love of reputation, which causes instinctive aversion to what is fitted to lower it, and was given us as a preservative from all that is properly shameful. To be lost to shame is to be nearly past hope. (Zephaniah 3:5; Jeremiah 6:15; Jeremiah 3:3). But when Christ and "His words" are unpopular, the same instinctive desire to stand well with others begets that temptation to be ashamed of Him which only the expulsive power of a higher affection can effectually counteract.

What is a man profited? etc. All the wealth, glory, pleasure and power of earth are worthless to the dying man. If he should gain them all and lose his own soul, he has lost all.
What shall a man give in exchange for his soul? What would a man not give? What is there that he can give, if in life he has not followed Christ?