The Prophet seems in other words to confirm what he had said, even that the memory of afflictions overwhelmed his soul. For the soul is said to be humbled in or upon man, when he lies down under the burden of despair. It is the soul that raises man up, and as it were revives him; but when the soul is cast as it were on man, it is a most grievous thing; for it is better to lie down a dead body than to have this additional burden, which makes the case still worse. A dead body might indeed lie on the ground without strength and motion, but it may still retain its own place; but when the soul is thus cast down, it is said to press down man, though lifeless, more and more. This then is what the Prophet means. And yet he says that he was so occupied with this remembrance, that he could not thence withdraw his mind. There is no doubt but that he also intended here to confess his own infirmity, and that of all the faithful; and the reason of this we have already explained. Then relying on this doctrine, even when all our thoughts press us down, and not only lead us to despair, but also hurry us on and cast us headlong into it, let us learn to flee even then to God and to lay before him all our complaints, and let us not be ashamed, because we see that this mode of proceeding is suggested to us by the Holy Spirit. It follows, --

By soul - is humbled in me - It is evident that in the preceding verses there is a bitterness of complaint against the bitterness of adversity, that is not becoming to man when under the chastising hand of God; and, while indulging this feeling, all hope fled. Here we find a different feeling; he humbles himself under the mighty hand of God, and then his hope revives, Lamentations 3:21.

My soul hath [them] still in remembrance, and is humbled (h) in me.
(h) He shows that God thus uses to exercise his, to the intent that by this they may know themselves, and feel his mercies.

My soul hath them still in remembrance,.... That is, according to our version, affliction and misery, compared to wormwood and gall: but the words, "my soul", are fetched from the next clause, where they ought to stand, and this to be rendered, "in remembering thou wilt remember" (t); or, "thou wilt surely remember", and so expresses the confidence of the prophet, and his firm belief, his faith and hope increasing in prayer, that God would in much mercy remember his people, and their afflictions, and save them out of them:
and is humbled in me; both under the afflicting hand of God, and in view and hope of his mercy: though rather it should be rendered, "and" or "for my soul meditateth within me" (u); says or suggests such things to me, that God will in wrath remember mercy; see Psalm 77:7. So Jarchi makes mention of a Midrash, that interprets it of his soul's waiting till the time that God remembers.
(t) "recordando recordaberis", Luther, Michaelis. (u) "meditatur apud me anima mea", Junius & Tremellius; "et animo meo meditor", Castalio.

As often as my soul calls them to remembrance, it is humbled or bowed down in me.