And they shall never perish. It is an inestimable fruit of faith, that Christ bids us be convinced of our security when we are brought by faith into his fold. But we must also observe on what foundation this certainty rests. It is because he will be a faithful guardian of our salvation, for he testifies that our salvation is in his hand And if this were not enough, he says that they will be safely guarded by the power of his Father This is a remarkable passage, by which we are taught that the salvation of all the elect is not less certain than the power of God is invincible. Besides, Christ did not intend to throw this word foolishly into the air, but to give a promise which should remain deeply axed in their minds; and, therefore, we infer that the statement of Christ is intended to show that the elect are absolutely certain of their salvation. We are surrounded, indeed, by powerful adversaries, and so great is our weakness, that we are every moment in imminent danger of death; but as He who keeps what we have committed to him (2-Timothy 1:12) is greater or more powerful than all, we have no reason to tremble as if our life were in danger. Hence, too, we infer how mad is the confidence of the Papists, which relies on free-will, on their own virtue, and on the merits of their works. Widely different is the manner in which Christ instructs his followers, to remember that, in this world, they may be said to be in the midst of a forest, surrounded by innumerable robbers, and are not only unarmed and exposed as a prey, but are aware that the cause of death is contained in themselves, so that, relying on the guardianship of God alone, they may walk without alarm. In short, our salvation is certain, because it is in the hand of God; for our faith is weak, and we are too prone to waver. But God, who has taken us under his protection, is sufficiently powerful to scatter, with his breath alone, all the forces of our adversaries. It is of great importance for us to turn our eye to this, that the fear of temptations may not dismay us; for Christ even intended to point out the way in which sheep are made to live at ease in the midst of wolves. And none can wrest them out of my Father's hand. The word and, in this passage, means therefore For, since the power of God is invincible, Christ infers that the salvation of believers is not exposed to the ungovernable passions of their enemies, because, ere they perish, God must be overcome, who has taken them under the protection of his hand.

I give unto them eternal life - See John 5:24.
Shall never perish - To perish here means to be destroyed, or to be punished in hell. Matthew 10:28; "which is able to destroy (the same word) both soul and body in hell." Matthew 18:14; "it is not the will of your Father which is in heaven that one of these little ones should perish." John 3:15; "that whosoever believeth in him should not perish" Romans 2:12; They who have sinned without law shall also perish without law" John 17:12; 1-Corinthians 1:18. In all these places the word refers to future punishment, and the declaration of the Saviour is that his followers, his true disciples, shall never be cast away. The original is expressed with remarkable strength: "They shall not be destroyed forever." Syriac: "They shall not perish to eternity." This is spoken of all Christians - that is, of all who ever possess the character of true followers of Christ, and who can be called his flock.
Shall any - The word "any" refers to any power that might attempt it. It will apply either to men or to devils. It is an affirmation that no man, however eloquent in error, or persuasive in infidelity, or cunning: in argument, or mighty in rank; and that no devil with all his malice, power, cunning, or allurements, shall be able to pluck them from his hand,
Pluck them - In the original to rob; to seize and bear away as a robber does his prey. Jesus holds them so secure and so certainly that no foe can surprise him as a robber does, or overcome him by force.
My hand - The hand is that by which we hold or secure an object. It means that Jesus has them safely in his own care and keeping. Compare Romans 8:38-39.

They shall never perish - Why? Because they hear my voice, and follow me; therefore I know, I approve of and love them, and give them eternal life. They who continue to hear Christ's voice, and to follow him, shall never perish. They give themselves up to God - believe so on Jesus that he lives in their hearts: God hath given unto them eternal life, and this life is in his Son; and he that hath the Son hath life, 1-John 5:11, 1-John 5:12. Now it is evident that only those who have Christ living in and governing their souls, so that they possess the mind that was in him, are his sheep - are those that shall never perish, because they have this eternal life abiding in them: therefore to talk of a man's being one of the elect - one that shall never perish - one who shall have eternal life - who shall never be plucked out of the hand of God, etc., while he lives in sin, has no Christ in his heart, has either never received or fallen away from the grace of God, is as contrary to common sense as it is to the nature and testimonies of the Most High. Final perseverance implies final faithfulness - he that endures to the end shall be saved - he that is faithful unto death shall have a crown of life. And will any man attempt to say that he who does not endure to the end, and is unfaithful, shall ever enter into life?

And I give unto them eternal life,.... Christ gives eternal life to his sheep, or people now; he gives them a spiritual life, or a life of grace, which issues in eternal life; he gives them himself, who is the true God and eternal life, and whoever has him has life; he gives them the knowledge of himself, which is life eternal; and he gives them his righteousness, which is their justification of life, or what entitles them to eternal life; and he gives them the foretastes of it, in faith and hope, in the enjoyment of himself, and the discoveries of his love; he gives them the earnest and pledge of it, his own Spirit; and they have this life in him as their representative, and it is hid with him in God, and is safe and secure for them; and he will actually give it to them in their own persons, to be for ever enjoyed by them; and because of the certainty of it, he is said to do it now: this is a pure gift, it is of grace, and not of works; and it is in the gift of Christ as Mediator, who has power to give it to as many as the Father has given him:
and they shall never perish; though they were lost in Adam, and in a perishing condition in themselves, during their state of unregeneracy; in which condition they see themselves to be, when convinced by the Spirit of God; and come as persons ready to perish to Christ, as a Saviour, resolving, that if they perish, they will perish at his feet: and though after conversion, they are subject to many falls and spiritual declensions, and lose their peace, joy, and comfort, and imagine their strength and hope are perished, or at least fear they shall one day perish through one sin, or snare, or temptation or another, yet they shall never perish in such sense as the wicked will; they will not be punished with everlasting destruction from the presence of the Lord, and the glory of his power:
neither shall any pluck them out of my hand; Christ's sheep are in his hands, being put there by God the Father, both as an instance of his love to Christ, and them; and this was done from all eternity, even when they were chosen in him; so that they were in the hands of Christ, before they were in the loins of Adam; and were preserved in him, notwithstanding Adam's fall, and through the ruins of it. To be in the hands of Christ, is to be high in his esteem and favour; the saints are a crown of glory in the hand of the Lord, and a royal diadem in the hand of their God; they are a signet on his right hand that shall never be plucked off; they are engraven on the palms of his hands: to be in the hands of Christ, is to be in his possession, and at his dispose, as all the elect of God are; and to be under his guidance, care, and protection, as they be; they are fed according to the integrity of his heart, and guided by the skilfulness of his hands; they are always under his care and watchful eye, who protects them from all their enemies, and hides them in the hollow of his hand: hence, because they are so, they are called "the sheep of his hand", Psalm 95:7. And none shall ever pluck them from thence; no man can do it, not any false teacher can remove them from Christ, by all the art and cunning he is master of; nor any violent persecutor, by all the force and power he can use; nor can any sin, or snare, or temptation, draw them out of Christ's hands; nor any adversity whatever separate them from him: they must be safe, and always abide there, who are in the hands of Christ; for his hands have laid the foundations of the heavens and the earth, they grasp the whole universe, and hold all things together; and who then can pluck any out of these hands? Moreover, Christ, as Mediator, has all power in heaven and earth; and even as man, he is the man of God's right hand, made strong for himself.

I give unto them eternal life--not "will give them"; for it is a present gift. (See on John 3:36; John 5:24). It is a very grand utterance, couched in the language of majestic authority.

I give unto them eternal life. To his sheep. Eternal life means, not eternal existence, but eternal bliss. God hath made the soul deathless, but it may exist in banishment from heaven.