In the fulness of his sufficiency - When he seems to have an abundance.
He shall be in straits - Either by the dread of calamity, or because calamity shall come suddenly upon him, and his property shall be swept away. When everything seemed to be abundant he should be reduced to want.
Every hand of the wicked shall come upon him - Margin, "or, troublesome" The meaning is, that all that the wretched or miserable endure should come suddenly upon him. Rosenmuller suggests, however, that it means that all the poor, and all who had been oppressed and robbed by him, would suddenly come upon him to recover their own property, and would scatter all that he had. The general meaning is clear, that he would be involved in misery from every quarter, or on every hand.

In the fullness of his sufficiency he shall be in straits - This is a fine saying, and few of the menders of Job's text have been able to improve the version. It is literally true of every great, rich, wicked man; he has no God, and anxieties and perplexities torment him, notwithstanding he has his portion in this life.
Every hand of the wicked shall come upon him - All kinds of misery shall be his portion. Coverdale translates: Though he had plenteousnesse of every thinge, yet was he poore; and, therefore, he is but a wretch on every syde.

In the fulness of his sufficiency he shall be in straits: every hand (l) of the wicked shall come upon him.
(l) The wicked will never be in rest: for one wicked man will seek to destroy another.

In the fulness of his sufficiency he shall be in straits,.... For though he may not only have a sufficient competency to live upon, but even a fulness of temporal blessings, have as much as heart can wish, or more, even good things, and plenty of them laid up for many years; yet amidst it all shall be reduced to the utmost straits and difficulties, either through fear of losing what he has, insomuch that his abundance will not suffer him to sleep in the night, nor to enjoy an hour's pleasure in the day; or being so narrow spirited, notwithstanding his fulness, that he cannot allow himself to eat of the fruit of his labours, and rejoice therein; or fearing, notwithstanding all his plenty, that he shall come to want and poverty; or rather while he is in the most flourishing circumstances, and in the height of his prosperity, he is suddenly, as Nebuchadnezzar was, dispossessed of all, and reduced to the utmost extremity, Daniel 4:31; the Targum is,
"when his measure is filled, he shall take vengeance on him:''
every hand of the wicked shall come upon him: or of the labourer, as the Targum, the hire of whose labour he has detained, or has taken away from him that which he laboured for; and so Broughton,
"the hand of the injured or grieved;''
such as he had been injurious to, and had grieved by his oppressions of them; or rather every troublesome wicked man, the hand of every thief or robber; respect seems to be had to the hand of the Sabeans and Chaldeans, that had been on Job and his substance.

shall be--rather, "he is (feeleth) straitened." The next clause explains in what respect.
wicked--Rather, "the whole hand of the miserable (whom he had oppressed) cometh upon him"; namely, the sense of his having oppressed the poor, now in turn comes with all its power (hand) on him. This caused his "straitened" feeling even in prosperity.

In, &c. - In the height of prosperity he shall be distressed. Hand, &c. - So his wickedness shall be punished by those as wicked as himself.