Upright men shall be astonished at this - At the course of events in regard to me. They will be amazed that God has suffered a holy man to be plunged into such calamities, and to be treated in this manner by his friends. The fact at which he supposes they would be so much astonished was, that the good were afflicted in this manner, and that no relief was furnished.
And the innocent shall stir up himself - Shall rouse himself, or assume vigor to resist the wicked.
The hypocrite - The wicked - alluding probably to his professed friends. The idea of hypocrisy which the sentence conveys arises from the fact, that they professed to be "his" friends, and had proved to be false; and that they had professed to be the friends of God, and yet had uttered sentiments inconsistent with any right views of him. He now says, that that could not go unnoticed. The world would be aroused at so remarkable a state of things, and a just public indignation would be the result.

Upright men shall be astonied - In several of these verses Job is supposed to speak prophetically of his future restoration, and of the good which religious society should derive from the history of his original affluence, consequent poverty and affliction, and final restoration to health, peace, and prosperity. The upright will receive the account with astonishment, and wonder at the dispensations of the Almighty; while hypocrites, false professors and the sour-headed, godly, shall be unmasked, and innocent men, whether in affliction or affluence, shall be known to be favourites of the Almighty.

Upright [men] shall be astonied at (i) this, and the innocent shall stir up himself against the hypocrite.
(i) That is, when they see the godly punished: but in the end they will come to understanding and know what will be the reward of the hypocrite.

Upright men shall be astonished at this,.... Such as were upright in heart, and in their walk conversation, sincere and honourable in their profession of religion, these would be amazed at the afflictions of Job, and the unkindness of his friends; it is hereby suggested, that it would be then, and in ages to come, a matter of surprise to truly gracious persons, when they should hear of such sore afflictions laid upon so good a man, and he told what censures, calumnies, and reproaches, were cast upon him by his friends; this would be so astonishing, that they would not know how to believe it, and still more at a loss how to account for it, that such things should be permitted in Providence, there being reason to believe the truth of them:
and the innocent shall stir up himself against the hypocrite; that is, such, who though they are not free from sin, yet live holy and harmless lives and conversations among men, so that they are not chargeable with any gross iniquity, or what is scandalous and unbecoming their character; these shall rise up with indignation against such persons as pretend to a great deal of sanctify and devotion, and yet have no charity or love to an afflicted saint, but censure and reproach him, and add affliction to his affliction. Thus Job retorts the charge of hypocrisy his friends brought against him upon them; for he seems tacitly to design them, and delivers these words as a kind of solace to himself; that though he was thus used by them at that time, yet good men in future time would have different apprehensions of him, and rise up and vindicate his name and character.

astonied--at my unmerited sufferings.
against the hypocrite--The upright shall feel their sense of justice wounded ("will be indignant") because of the prosperity of the wicked. By "hypocrite" or "ungodly," he perhaps glances at his false friends.

Astonied - At the depth and mysteriousness of God's judgments, which fall on innocent men, while the worst of men prosper. Yet - Notwithstanding all these sufferings of good men, and the astonishment which they cause, he shall the more zealously oppose those hypocrites, who make these strange providences of God an objection to religion.