Thou shalt call, and I will answer thee - This is language taken from courts of justice. It refers, probably, not to a future time, but to the present. "Call thou now, and I will respond." It expresses a desire to come at once to trial; to have the matter adjusted before he should leave the world. He could not bear the idea of going out of the world under the imputations which were lying on him, and he asked for an opportunity to vindicate himself before his Maker; compare the notes at Job 9:16.
Thou wilt have a desire to the work of thine hands - To me, one of thy creatures. This should, with more propriety, be rendered in the imperative, "do thou have a desire." It is the expression of an earnest wish that God would show an interest in him as one of his creatures, and would bring the matter to a speedy issue. The word here rendered, "have a desire" (תכסף tı̂kâsaph), means literally to be or become "pale" (from כסף keseph), "silver," so called from its paleness, like the Greek ἄργυρος arguros from ἀγρός agros, white); and then the verb means to pine or long after anything, so as to become pale.

Thou shalt call - Thou shalt say There shall be time no longer: Awake, ye dead! and come to judgment!
And I will answer thee - My dissolved frame shall be united at thy call; and body and soul shall be rejoined.
Thou wilt have a desire - תכסף tichsoph, "Thou wilt pant with desire;" or, "Thou wilt yearn over the work of thy hands." God has subjected the creature to vanity, in hope; having determined the resurrection. Man is one of the noblest works of God. He has exhibited him as a master-piece of his creative skill, power, and goodness. Nothing less than the strongest call upon justice could have induced him thus to destroy the work of his hands. No wonder that he has an earnest desire towards it; and that although man dies, and is as water spilt upon the ground that cannot be gathered up again; yet doth he devise means that his banished be not expelled from him. Even God is represented as earnestly longing for the ultimate reviviscence of the sleeping dust. He cannot, he will not, forget the work of his hands.

Thou shalt call, and I will (h) answer thee: thou wilt have a desire to the work of thine hands.
(h) Though I am afflicted in this life, yet in the resurrection I will feel your mercies and answer when you call me.

Thou shall call, and I will answer thee,.... Either at death, when the soul of than is required of him, and he is summoned out of time into eternity, and has sometimes previous notice of it; though not by a prophet, or express messenger from the Lord, as Hezekiah had, yet by some disease and distemper or another, which has a voice, a call in it to expect a remove shortly; and a good man that is prepared for it, he answers to this call readily and cheerfully; death is no king of terrors to him, he is not reluctant to it, yea, desirous of it; entreats his dismission in peace, and even longs for it, and rejoices and triumphs in the views of it: or else at the resurrection, when Christ shall call to the dead, as he did to Lazarus, and say, Come forth; and when they shall hear his voice, even the voice of the archangel, and shall answer to it, and come forth out of their graves, the sea, death, and the grave, being obliged to deliver up the dead that are therein; though some think this refers to God's call unto him in a judicial way, and his answers to it by way of defence, as in Job 13:22; but the other sense seems more agreeable to the context:
thou wilt have a desire to the work of thine hands; meaning his body, which is the workmanship of God, and a curious piece of workmanship it is, wonderfully and fearfully made, Psalm 139:14, and curiously wrought; and though it may seem to be marred and spoiled by death, yet God will have a desire to the restoration of it at the resurrection to a better condition; even the bodies of his people, and that because they are vessels chosen by him, given to his Son, redeemed by his blood, united to his person, and sanctified by his Spirit, whose temples they are, and in whom he dwells: wherefore upon these considerations it may be reasonably supposed that Father, Son, and Spirit, have a desire to the resurrection of the bodies of the saints, and in which they will have a concern; and from which it may be concluded it will be certainly effected, since God is a rock, and his work is perfect, or will be, both upon the bodies and souls of his people; and the work of sanctification will not be properly completed on them until their vile bodies are changed, and made like to the glorious body of Christ; which must be very desirable to him, who has such a special love for them, and delight in them. Some render the words with an interrogation, "wilt thou desire to destroy the work of thine hands" (e)? surely thou wilt not; or, as Ben Gersom,
"is it fit that thou shouldest desire to destroy the work of thine hands?''
surely it is not becoming, it cannot be thought that thou wilt do it; but the former sense is best.
(e) "perdere desiderabis?" Pagninus, Vatablus.

namely, at the resurrection (John 5:28; Psalm 17:15).
have a desire to--literally, "become pale with anxious desire:" the same word is translated "sore longedst after" (Genesis 31:30; Psalm 84:2), implying the utter unlikelihood that God would leave in oblivion the "creature of His own hands so fearfully and wonderfully made." It is objected that if Job knew of a future retribution, he would make it the leading topic in solving the problem of the permitted afflictions of the righteous. But, (1) He did not intend to exceed the limits of what was clearly revealed; the doctrine was then in a vague form only; (2) The doctrine of God's moral government in this life, even independently of the future, needed vindication.

Answer thee - Thou shalt call my soul to thyself: and I will chearfully answer, Here I am: knowing thou wilt have a desire to the work of thy hands - A love for the soul which thou hast made, and new - made by thy grace.