Thou knowest that I am not wicked - That is, that I am not a hypocrite, or an impenitent sinner. Job did not claim perfection (see the note at Job 9:20), but he maintained through all this argument that he was not a wicked man, in the sense in which his friends regarded him as such, and for the truth of this he could boldly appeal to God. The margin is, "It is upon thy knowledge." This is a literal translation of the Hebrew, but the sense is well expressed in the text. The meaning of the verse is, "Why dost thou thus afflict me, when thou knowest that I am not wicked? Why am I treated as if I were the worst of men? Why is occasion thus furnished for my friends to construct an argument as if I were a man of singular depravity?"
There is none that can deliver out of thine hand - I have no power to release myself. Job felt hat God had almighty power; and he seems to have felt that his sufferings were rather the simple exertion of power, than the exercise of justice. It was this that laid the foundation for his complaint.

Thou knowest that I am not wicked - While thou hast this knowledge of me and my conduct, why appear to be sifting me as if in order to find out sin; and though none can be found, treating me as though I were a transgressor?

Thou knowest that I am not (i) wicked; and [there is] none that can deliver out of thine hand.
(i) By affliction you keep me as in a prison, and restrain me from doing evil, neither can any set me free.

Thou knowest that I am not wicked,.... Or "in", or "upon thy knowledge (a) it is that I am not wicked"; it is a thing well known, quite clear, and manifest, without making such a search and inquiry: not that he thought himself without sin, and could appeal to the omniscience of God for the truth of that; for he had confessed before that he was a sinner, and wicked, as to his nature and birth, and the many infirmities of life; see Job 7:20; but that he was not that wicked person, and an hypocrite, as his friends took him to be, and as might be concluded from the sore afflictions that were upon him; he did not live in sin, nor indulge himself in a vicious course of life; sin had not the dominion over him, and he had not secretly cherished any reigning iniquity, and lived in the commission of it: and for the truth of this he could appeal to the searcher of hearts; and yet he so closely pursued, and so strictly examined him, as if he suspected he was thus guilty:
and there is none that can deliver out of thine hand; that is, out of his afflicting hand, until he please to release him from it himself; for this is not to be understood of deliverance from the avenging hand of justice, from hell and wrath, and everlasting destruction; for there is one that can and does deliver his people from sin and Satan; from the world, the law, its curses and condemnation, and from wrath to come; and from the hands of justice, having made full satisfaction to it: but what Job observes that God knew was, that neither he himself, nor any angel, nor man, nor any creature, could take him out of his hand in which be was; and therefore suggests, not only that his condition was extremely bad, distressed, and miserable, but that there was no necessity for God to he so quick upon him, and so strict in his inquiry into him; nor of enclosing him about on all hands with afflictions, since, there was no danger of his escaping from him, or of others assisting him in and facilitating such an attempt: and this he full well knew; for so the words are connection with the preceding: "and thou knowest that there is none", &c. (b), as well as with what follows, as some think.
(a) "in notitia tua est", Junius & Tremellius, Piscator, Beza; so Michaelis. (b) So Bolducius, Drusius, Schmidt, Michaelis, and Bar Tzemach.

"Although Thou (the Omniscient) knowest," &c. (connected with Job 10:6), "Thou searchest after my sin."
and . . . that none that can deliver out of thine hand--Therefore Thou hast no need to deal with me with the rapid violence which man would use (see Job 10:6).

Wicked - An hypocrite, as my friends account me. Deliver - But thou art the supreme ruler of the world; therefore I must wait thy time, and throw myself on thy mercy, in submission to thy sovereign will.