And after that men began to be multiplied upon the earth, and daughters were born to them.

And it came to pass when mankind began to multiply on the earth, and daughters were born to them,

And it cometh to pass that mankind have begun to multiply on the face of the ground, and daughters have been born to them,

And after a time, when men were increasing on the earth, and had daughters,

Et fuit, quum coepis sent homines multiplicari in superficie terrae, filiaeque natae essent eis:

And it came to pass, when men began to multiply. Moses, having enumerated in order, ten patriarchs, with whom the worship of God remained pure, now relates, that their families also were corrupted. But this narration must be traced to an earlier period than the five hundredth year of Noah. For, in order to make a transition to the history of the deluge, he prefaces it by declaring the whole world to have been so corrupt, that scarcely anything was left to God, out of the widely spread defection. That this may be the more apparent, the principle is to be kept in memory, that the world was then as if divided into two parts; because the family of Seth cherished the pure and lawful worship of Good, from which the rest had fallen. Now, although all mankind had been formed for the worship of God, and therefore sincere religion ought everywhere to have reigned; yet since the greater part had prostituted itself, either to an entire contempt of God, or to depraved superstitions; it was fitting that the small portion which God had adopted, by special privilege, to himself, should remain separate from others. It was, therefore, base ingratitude in the posterity of Seth, to mingle themselves with the children of Cain, and with other profane races; because they voluntarily deprived themselves of the inestimable grace of God. For it was an intolerable profanation, to pervert, and to confound, the order appointed by God. It seems at first sight frivolous, that the sons of God should be so severely condemned, for having chosen for themselves beautiful wives from the daughters of men. But we must know first, that it is not a light crime to violate a distinction established by the Lord; secondly, that for the worshippers of God to be separated from profane nations, was a sacred appointment which ought reverently to have been observed, in order that a Church of God might exist upon earth; thirdly, that the disease was desperate, seeing that men rejected the remedy divinely prescribed for them. In short, Moses points it out as the most extreme disorder; when the sons of the pious, whom God had separated to himself from others, as a peculiar and hidden treasure, became degenerate. That ancient figment, concerning the intercourse of angels with women, is abundantly refuted by its own absurdity; and it is surprising that learned men should formerly have been fascinated by ravings so gross and prodigious. The opinion also of the Chaldean paraphrase is frigid; namely, that promiscuous marriages between the sons of nobles, and the daughters of plebeians, is condemned. Moses, then, does not distinguish the sons of God from the daughters of men, because they were of dissimilar nature, or of different origin; but because they were the sons of God by adoption, whom he had set apart for himself; while the rest remained in their original condition. Should any one object, that they who had shamefully departed from the faith, and the obedience which God required, were unworthy to be accounted the sons of God; the answer is easy, that the honor is not ascribed to them, but to the grace of God, which had hitherto been conspicuous in their families. For when Scripture speaks of the sons of God, sometimes it has respect to eternal election, which extends only to the lawful heirs; sometimes to external vocations according to which many wolves are within the fold; and thought in fact, they are strangers, yet they obtain the name of sons, until the Lord shall disown them. Yea, even by giving them a title so honorable, Moses reproves their ingratitude, because, leaving their heavenly Father, they prostituted themselves as deserters.

When men began to multiply - It was not at this time that men began to multiply, but the inspired penman speaks now of a fact which had taken place long before. As there is a distinction made here between men and those called the sons of God, it is generally supposed that the immediate posterity of Cain and that of Seth are intended. The first were mere men, such as fallen nature may produce, degenerate sons of a degenerate father, governed by the desire of the flesh, the desire of the eye, and the pride of life. The others were sons of God, not angels, as some have dreamed, but such as were, according to our Lord's doctrine, born again, born from above, John 3:3, John 3:5,John 3:6, etc., and made children of God by the influence of the Holy Spirit, Galatians 5:6. The former were apostates from the true religion, the latter were those among whom it was preserved and cultivated. Dr. Wall supposes the first verses of this chapter should be paraphrased thus: "When men began to multiply on the earth, the chief men took wives of all the handsome poor women they chose. There were tyrants in the earth in those days; and also after the antediluvian days powerful men had unlawful connections with the inferior women, and the children which sprang from this illicit commerce were the renowned heroes of antiquity, of whom the heathens made their gods."

And it came to pass, when men began to multiply upon the face of the earth,.... Either mankind in general, or rather the posterity of Cain, who were mere natural men, such as they were when born into the world, and as brought up in it, destitute of the grace of God, and of the knowledge and fear of him; and who in proportion much more multiplied than the posterity of Seth, because of the practice of polygamy, which by the example of Lamech, one of that race, might prevail among them:
and daughters were born unto them; not daughters only, but sons also, though it may be more daughters than sons, or it may denote remarkable ones, for their beauty or immodesty, or both; and chiefly this is observed for the sake of what follows.

The most remarkable thing concerning the old world, is the destroying of it by the deluge, or flood. We are told of the abounding iniquity of that wicked world: God's just wrath, and his holy resolution to punish it. In all ages there has been a peculiar curse of God upon marriages between professors of true religion and its avowed enemies. The evil example of the ungodly party corrupts or greatly hurts the other. Family religion is put an end to, and the children are trained up according to the worldly maxims of that parent who is without the fear of God. If we profess to be the sons and daughters of the Lord Almighty, we must not marry without his consent. He will never give his blessing, if we prefer beauty, wit, wealth, or worldly honours, to faith and holiness. The Spirit of God strove with men, by sending Enoch, Noah, and perhaps others, to preach to them; by waiting to be gracious, notwithstanding their rebellions; and by exciting alarm and convictions in their consciences. But the Lord declared that his Spirit should not thus strive with men always; he would leave them to be hardened in sin, and ripened for destruction. This he determined on, because man was flesh: not only frail and feeble, but carnal and depraved; having misused the noble powers of his soul to gratify his corrupt inclinations. God sees all the wickedness that is among the children of men; it cannot be hid from him now; and if it be not repented of, it shall be made known by him shortly. The wickedness of a people is great indeed, when noted sinners are men renowned among them. Very much sin was committed in all places, by all sorts of people. Any one might see that the wickedness of man was great: but God saw that every imagination, or purpose, of the thoughts of man's heart, was only evil continually. This was the bitter root, the corrupt spring. The heart was deceitful and desperately wicked; the principles were corrupt; the habits and dispositions evil. Their designs and devices were wicked. They did evil deliberately, contriving how to do mischief. There was no good among them. God saw man's wickedness as one injured and wronged by it. He saw it as a tender father sees the folly and stubbornness of a rebellious and disobedient child, which grieves him, and makes him wish he had been childless. The words here used are remarkable; they are used after the manner of men, and do not mean that God can change, or be unhappy. Does God thus hate our sin? And shall not we be grieved to the heart for it? Oh that we may look on Him whom we have grieved, and mourn! God repented that he had made man; but we never find him repent that he redeemed man. God resolves to destroy man: the original word is very striking, 'I will wipe off man from the earth,' as dirt or filth is wiped off from a place which should be clean, and is thrown to the dunghill, the proper place for it. God speaks of man as his own creature, when he resolves upon his punishment. Those forfeit their lives who do not answer the end of their living. God speaks of resolution concerning men, after his Spirit had been long striving with them in vain. None are punished by the justice of God, but those who hate to be reformed by the grace of God.

The genealogies in Genesis 4 and 5, which trace the development of the human race through two fundamentally different lines, headed by Cain and Seth, are accompanied by a description of their moral development, and the statement that through marriages between the "sons of God" (Elohim) and the "daughters of men," the wickedness became so great, that God determined to destroy the men whom He had created. This description applies to the whole human race, and presupposes the intercourse or marriage of the Cainites with the Sethites.

Men began to multiply upon the face of the earth - This was the effect of the blessing, Genesis 1:28, and yet man's corruption so abused this blessing, that it turned into a curse.