Their wine - Their system of doctrines and teaching, is the poison of dragons, etc., fatal and destructive to all them who follow it.

Their (r) wine [is] the poison of dragons, and the cruel venom of asps.
(r) The fruit of the wicked are as poison, detestable to God, and dangerous for man.

Their wine is the poison of dragons,.... Of these creatures, both land and sea dragons; see Gill on Micah 1:8; See Gill on Malachi 1:3; Pliny says (l) the dragon has no poison in it; yet, as Dalechamp, in his notes on that writer observes, he in many places prescribes remedies against the bite of the dragon; but Heliodorus (m) expressly speaks of some archers, whose arrows were infected with the poison of dragons; and Leo Africanus (n) says, the Atlantic dragons are exceeding poisonous: and yet other writers (o) besides Pliny have asserted that they are free from poison. It seems the dragons of Greece are without, but not those of Africa and Arabia; and to these Moses has respect, as being well known to him. The Targum of Jerusalem is,
"the poison of this people is like the poison of dragons as they drink wine;''and the Targum of Jonathan,"as the poison of dragons, when they are at or from their wine;''that is, after and as soon as they have drank it; for, according to natural historians, serpents, though they need and use but little drink, yet are very fond of wine: and it seems that thereby their poison becomes more sharp and intense, as Bochart (p) observes; wherefore the allusion is very proper and pertinent, and denotes the wine of fornication of the apostate church of Rome, frequently spoken of Revelation 14:8; which is no other than her corrupt doctrines, intoxicating, enticing, and leading to idolatry and superstition; and as the true Gospel of Christ is sometimes compared to wine, so the false doctrines of this church; but then it is such that is not only loathsome and abominable, but poisonous and pernicious to the souls of men, damnable and ruinous, and brings upon them swift destruction, 2-Peter 2:1; and may well be compared to the poison of dragons for such reasons; as also because they are doctrines of devils, and come from the great dragon, that old serpent called the devil and Satan, 2-Timothy 4:1,
and the cruel venom of asps; which, of all kind of serpents, Pliny (q) says is the least curable; nay, according to the Septuagint and Vulgate Latin versions of this clause, it is incurable; and so Aristotle says (r) there is no remedy for it; and so says Aelianus (s), who also observes (t), that the mark it makes is so small, that it is scarcely discerned by the sharpest eye. Pliny (u) represents it as a most revengeful creature; when its mate is killed by any, it will pursue the slayer, flee where he will, and as far and fast as he can: it breaks through all difficulties, and is not to be stopped by rivers, or any obstacles, and will attack the person, whom it presently knows, let him be in ever such a crowd: and therefore it and its poison may well be called cruel; and as the poison of this creature lies under its tongue, this is a fit simile to express the poisonous and pernicious doctrines of the apostate church.
(l) Nat. Hist. l. 29. c. 4. (m) Ethiopic. l. 9. c. 19. p. 438. (n) Descriptio Africae, l. 9. p. 763. (o) Aristot. Hist. Animal. l. 8. c. 4. Plin. Nat. Hist. l. 10. c. 72. (p) Hierozoic. par. 2. l. 3. c. 14. col. 438, 439. (q) Nat. Hist. l. 29. c. 4. (r) Hist. Animal. l. 8. c. 29. (s) De Animal. l. 1. c. 54. & l. 6. c. 38. (t) Ibid. l. 9. c. 61. (u) Nat. Hist. l. 8. c. 23.