Against the Lord, and his Christ. The Spirit teacheth by this word, that all those do make war against God which refuse to submit themselves to Christ; they do full little think this oftentimes, notwithstanding it is so that because God will reign in the person of his Son alone, we refuse to obey him so often as we rebel against Christ, as the Lord himself saith in John, "He which honoreth not the Son, honoreth not the Father." Wherefore let the hypocrites profess a thousand times that they mean nothing less than to make war against God, yet shall they find this true, that God is their open enemy, unless they embrace Christ with his gospel. The use of this doctrine is double, for it armeth us against all the terrors of the flesh, because we must not fear, lest they get the victory of God which withstand the gospel. Again, we must beware, lest, through the contempt of godly doctrine, we advance ourselves against God to our own destruction.

The kings of the earth - The Psalmist specifies more particularly that kings and rulers would be opposed to the Messiah. This had occurred already by the opposition made to the Messiah by the rulers of the Jewish people, and it would be still more evinced by the opposition of princes and kings as the gospel spread among the nations.
Stood up - The word used here παρίστημι paristēmi commonly means "to present oneself, or to stand forth, for the purpose of aiding, counseling," etc. But here it means that they "rose," or "presented themselves," to evince their opposition. They stood opposed to the Messiah, and offered resistance to him.
The rulers - This is another instance of the Hebrew parallelism. The word does not denote another class of people from kings, but expresses the same idea in another form, or in a more general manner, meaning that all classes of persons in authority would be opposed to the gospel.
Were gathered together - Hebrew, consulted together; were united in a consultation. The Greek implies that they were assembled for the purpose of consultation.
Against the Lord - In the Hebrew, "against Yahweh." This is the special name which is given in the Scriptures to God. They rose against his plan of appointing a Messiah, and against the Messiah whom he had chosen.
Against his Christ - Hebrew, against his Messiah, or his Anointed. See the notes on Matthew 1:1. This is one of the places where the word "Messiah" is used in the Old Testament. The word occurs in about 40 places, and is commonly translated "his anointed," and is applied to kings. The direct reference of the word to the Messiah in the Old Testament is not frequent. This passage implies that opposition to the Messiah is opposition to Yahweh. And this is uniformly supposed in the sacred Scriptures. He that is opposed to Christ is opposed to God. He that neglects him neglects God. He that despises him despises God, Matthew 10:40; Matthew 18:5; John 12:44-45; Luke 10:16, "He that despiseth me, despiseth him that sent me." The reasons of this are:
(1) That the Messiah is "the brightness of the Father's glory, and the express image of his person," Hebrews 1:3.
(2) he is equal with the Father, possessing the same attributes and the same power, John 1:1; Philippians 2:6.
(3) he is appointed by God to this great work of saving people. To despise him, or to oppose him, is to despise and oppose him who appointed him to this work, to contemn his counsels, and to set him at naught.
(4) his work is dear to God. It has engaged his thoughts. It has been approved by him. His mission has been confirmed by the miraculous power of the Father, and by every possible manifestation of his approbation and love. To oppose the Messiah is, therefore, to oppose what is dear to the heart of God, and which has long been the object of his tender solicitude. It follows from this, that they who neglect the Christian religion are exposing themselves to the displeasure of God, and endangering their everlasting interests. No man is safe who opposes God; and no man can have evidence that God will approve him who does not embrace the Messiah, whom He has appointed to redeem the world.

Against the Lord and against his Christ - Κατα του Χριστου αυτου should be translated, against his Anointed, because it particularly agrees with ὁν εχρισας, whom thou hast Anointed, in the succeeding verse.

The kings of the earth stood up,.... Herod Antipas, tetrarch of Galilee, sometimes called a king, Mark 6:14 and Pilate the Roman governor, who represented his master Caesar; these stood, or rose up in an hostile manner, and set themselves against, and opposed themselves to the Messiah, Jesus of Nazareth:
and the rulers were gathered together; the Jewish rulers, Annas, Caiaphas, and the rest of the members of the sanhedrim, who met together more than once; and particularly at the high priest's palace, to consult how they should take Jesus and put him to death; and who also gathered together at the same place, when he was taken, to arraign, examine, and condemn him. And this opposition, and these conspiracies and consultations, were
against the Lord: Jehovah, the Father of Christ, who sent him, and anointed him; so that what was done against Christ, was done against the Lord, their views and designs, their interest and glory, being the same:
and against his Christ; or anointed one, who was anointed by him, with the Holy Ghost, from his birth, and at his baptism, to be prophet, priest, and King.