And to knowledge temperance - On the meaning of the word "temperance," see the Acts 24:25 note, and 1-Corinthians 9:25 note. The word here refers to the mastery over all our evil inclinations and appetites. We are to allow none of them to obtain control over us. See the notes at 1-Corinthians 6:12. This would include, of course, abstinence from intoxicating drinks; but it would also embrace all evil passions and propensities. Everything is to be confined within proper limits, and to no propensity of our nature are we to give indulgence beyond the limits which the law of God allows.
And to temperance patience - Notes, James 1:4.
And to patience godliness - True piety. Notes, 2-Peter 1:3. Compare 1-Timothy 2:2; 1-Timothy 3:16; 1-Timothy 4:7-8; 1-Timothy 6:3, 1-Timothy 6:5-6, 1-Timothy 6:11.

Temperance - A proper and limited use of all earthly enjoyments, keeping every sense under proper restraints, and never permitting the animal part to subjugate the rational.
Patience - Bearing all trials and difficulties with an even mind, enduring in all, and persevering through all.
Godliness - Piety towards God; a deep, reverential, religious fear; not only worshipping God with every becoming outward act, but adoring, loving, and magnifying him in the heart: a disposition indispensably necessary to salvation, but exceedingly rare among professors.

(6) And to knowledge temperance; and to temperance patience; and to patience godliness;
(6) He brings up certain and other principal virtues, of which some pertain to the first table of the law, others to the last.

And to knowledge, temperance,.... Avoiding all excess in eating and drinking, and all impure and unclean lusts; for it signifies nothing what a man knows, or professes to know, if his life is a scene of intemperance and debauchery: this seems to be levelled against the followers or Simon Magus, who ascertained salvation to knowledge, though the life was ever so impure, Moreover, this may include abstinence, not only from hurtful lusts, but from the use of things indifferent, when the peace and comfort of a weak brother are endangered; for then to knowledge must be added love, otherwise that knowledge will not be right, at least not rightly used; see 1-Corinthians 8:1,
and to temperance, patience; which is necessary to the running of the Christian race, which is attended with many difficulties and exercises; and under affliction from the hand of God, that there be no murmuring nor repining; and under reproaches and persecutions from men, that they faint not, and are not discouraged by them; and in the expectation of the heavenly glory: this is proper to be superadded to the former, because there may be intemperance in passion, as well as in the use of the creatures; a man may be inebriated with wrath and anger, and overcome with impatience, as well as with wine and strong drink:
and to patience, godliness; either internal, which is distinguished from bodily exercise, or outward worship, and lies in the inward and powerful exercise of grace, as faith, hope, love, fear, &c. and the Syriac version here renders it, "the fear of God": or rather external, and intends the whole worship of God, as prayer, praise, hearing of the word, and attendance on all ordinances.

Greek, "And in your knowledge self-control." In the exercise of Christian knowledge or discernment of God's will, let there be the practical fruit of self-control as to one's lusts and passions. Incontinence weakens the mind; continence, or self-control, moves weakness and imparts strength And in your self-control patient endurance" amidst sufferings, so much dwelt on in the First Epistle, second, third, and fourth chapters. "And in your patient endurance godliness"; it is not to be mere stoical endurance, but united to [and flowing from] God-trusting [ALFORD].

And to your knowledge temperance; and to your temperance patience - Bear and forbear; sustain and abstain; deny yourself and take up your cross daily. The more knowledge you have, the more renounce your own will; indulge yourself the less. "Knowledge puffeth up," and the great boasters of knowledge (the Gnostics) were those that "turned the grace of God into wantonness." But see that your knowledge be attended with temperance. Christian temperance implies the voluntary abstaining from all pleasure which does not lead to God. It extends to all things inward and outward: the due government of every thought, as well as affection. "It is using the world," so to use all outward, and so to restrain all inward things, that they may become a means of what is spiritual; a scaling ladder to ascend to what is above. Intemperance is to abuse the world. He that uses anything below, looking no higher, and getting no farther, is intemperate. He that uses the creature only so as to attain to more of the Creator, is alone temperate, and walks as Christ himself walked. And to patience godliness - Its proper support: a continual sense of God's presence and providence, and a filial fear of, and confidence in, him; otherwise your patience may be pride, surliness, stoicism; but not Christianity.